CAJ | 학술논문

目的：研制可注射α‐CSH‐nano‐HA／PHBV‐PEG顺铂释药系统，为骨转移瘤提供新型的局部药物缓释系统。方法α‐CSH‐nano‐HA／PHBV‐PEG载顺铂制成可注射用α‐CSH‐nano‐HA／PHBV‐PEG cis‐platinum缓释微球，研究其结构、释药特性、可注射性以及力学性能。结果（1）第1、3、5、7天缓释微球的释药浓度分别为97．5、90．7、83．2、68．5μg／mL ，第7天后趋于稳定。（2）可注射α‐CSH‐nano‐HA／PHBV‐PEG顺铂释药系统在液固比为0．7时可注射性强，与此同时缓释药系统随着液固比的增大凝固时间延长。结论α‐CSH‐nano‐HA／PHBV‐PEG顺铂释药系统具有良好的注射性能和缓释作用。
목적：연제가주사α‐CSH‐nano‐HA／PHBV‐PEG순박석약계통，위골전이류제공신형적국부약물완석계통。방법α‐CSH‐nano‐HA／PHBV‐PEG재순박제성가주사용α‐CSH‐nano‐HA／PHBV‐PEG cis‐platinum완석미구，연구기결구、석약특성、가주사성이급역학성능。결과（1）제1、3、5、7천완석미구적석약농도분별위97．5、90．7、83．2、68．5μg／mL ，제7천후추우은정。（2）가주사α‐CSH‐nano‐HA／PHBV‐PEG순박석약계통재액고비위0．7시가주사성강，여차동시완석약계통수착액고비적증대응고시간연장。결론α‐CSH‐nano‐HA／PHBV‐PEG순박석약계통구유량호적주사성능화완석작용。
Objective To research and prepare of α‐calcium sulfate hydrate(CSH)‐nano‐hydroxyapatite(HA)/PHBV‐PEG cis‐platinum drug release system to provide the new type local drug sustained release system for meta‐static bone tumor .Methods Cis‐platinum was loaded into n‐HA by the ion exchange method .The drug loaded n‐HA was mixed with CSH(1∶1)and coated with compomer poly(3‐hydroxybutyrate‐hydroxyvalerate)(PHBV)and poly‐ethylene glycol(PEG) .The injectableα‐CSH‐nano‐HA/PHBV‐PEG cis‐platinum sustained release microspheres were prepared .The release characteristics ,injectability and mechanical property were researched .Results (1) The drug release concentration of the sustained release microspheres on 1 ,3 ,5 ,7 d the cis‐platinum concentration was 97 .5 , 90 .7 ,83 .2 ,68 .5μg/mL respectively ,and then the concentration trended to be stabilized .(2)When the liquid/solid ra‐tio was 0 .7 ,the injectableα‐CSH‐nano‐HA/PHBV‐PEG cis‐platinum drug delivery system has a strong injectability . At the same time the coagulation time was extended along with the increase of liquid/solid ratio .Conclusion Theα‐CSH‐nano‐HA/PHBV‐PEG cis‐platinum drug delivery system has the better in vitro releasing effect and injection property .