CAJ | 학술논문

目的：检测肺炎支原体肺炎（ MPP）患儿机体细胞免疫功能的变化，为MPP免疫学治疗提供进一步依据。方法：选取2013年7～12月于本院确诊为MPP的患儿60例，对照组为同期门诊体检健康儿童60例，分别检测两组儿童外周静脉血中T淋巴细胞亚群的表达水平。结果：MPP组患儿的CD3+、CD4+、CD8+、CD4+／CD8+表达水平（ xˉ±s，％）分别为69.12±8.07、37.76±8.22、27.96±9.28、1.53±0.56。与健康对照组儿童相比，MPP组患儿的CD3+、CD4+、CD4+／CD8+表达水平显著下降，而CD8+表达水平则显著升高（ P＜0.01）。结论：MPP患儿T淋巴细胞亚群表达失调，细胞免疫功能紊乱可能在MPP发病过程中起着重要作用。
목적：검측폐염지원체폐염（ MPP）환인궤체세포면역공능적변화，위MPP면역학치료제공진일보의거。방법：선취2013년7～12월우본원학진위MPP적환인60례，대조조위동기문진체검건강인동60례，분별검측량조인동외주정맥혈중T림파세포아군적표체수평。결과：MPP조환인적CD3+、CD4+、CD8+、CD4+／CD8+표체수평（ xˉ±s，％）분별위69.12±8.07、37.76±8.22、27.96±9.28、1.53±0.56。여건강대조조인동상비，MPP조환인적CD3+、CD4+、CD4+／CD8+표체수평현저하강，이CD8+표체수평칙현저승고（ P＜0.01）。결론：MPP환인T림파세포아군표체실조，세포면역공능문란가능재MPP발병과정중기착중요작용。
Objective:To detect the changes of T lymphocyte subsets in children with mycoplasma pneumoniae pneumonia ( MPP) for basis with immuno-logical therapy for MPP.Methods:Sixty children diagnosed as MPP in our hospital between July 2013 and December 2013 were included,and another 60 healthy children undergoing the physical examination at the out-patient in the corresponding period were recruited as controls.The peripheral blood was ob-tained from the two groups and measured for the levels of T lymphocyte subsets.Results:The levels of CD3 +,CD4 +,CD8 +and CD4 +/CD8 +were 69.12 ±8.07,37.76 ±8.22,27.96 ±9.28 and 1.53 ±0.56,respectively,for the in MPP group,whose CD3 +,CD4 +and CD4 +/CD8 +levels were signifi-cantly decreased,yet CD8 +level was markedly elevated as compared with the controls(P<0.01).Conclusion:Imbalanced T lymphocyte subsets were found in children with MPP,which suggests that cellular immune dysfunction may play an important role in the pathogenesis of mycoplasma pneumoniae pneumonia.