湘南学院学报（医学版）
湘南學院學報（醫學版）
상남학원학보（의학판）
JOURNAL OF XIANGNAN UNIVERSITY(MEDICAL SCIENCES)
2014年
4期
17-19
,共3页
晏桂华%朱伟群%侯雁如%肖和平
晏桂華%硃偉群%侯雁如%肖和平
안계화%주위군%후안여%초화평
金水六君煎%支气管哮喘%白介素-4%白介素-12%疗效
金水六君煎%支氣管哮喘%白介素-4%白介素-12%療效
금수륙군전%지기관효천%백개소-4%백개소-12%료효
Jinshui-six Decoction%Asthma%Interleukine-4%Interleukine-12%Curative effect
目的：观察金水六君煎加减对支气管哮喘急性期患者血清白介素-4(IL-4)和白介素-12(IL-12)的影响及疗效。方法将支气管哮喘急性期患者59例随机分为对照组(29例)和治疗组(30例)。对照组采用常规治疗,治疗组在对照组的基础上加金水六君煎加减治疗。入院时和治疗1周后空腹采上肢静脉血3 ml,抗凝,测定血清IL-4和IL-12浓度,并比较两组临床疗效。结果治疗组治愈9例(30.0%)、显效20例(66.7%)、无效1例(3.3%),对照组治愈5例(17.2%)、显效20例(69.0%)、无效4例(13.8%),两组比较差异有统计学意义(P<0.05)。与治疗前比较,治疗1周后两组患者血清IL-4浓度均降低,IL-12浓度均升高(P<0.05)；治疗1周后,治疗组血清IL-4浓度低于对照组,IL-12浓度高于对照组(P<0.05)。结论金水六君煎加减能协同西药调节哮喘患者血液中炎症促进因子与炎症抑制因子平衡失调,抑制炎症反应,提高治疗效果,值得临床推广。
目的：觀察金水六君煎加減對支氣管哮喘急性期患者血清白介素-4(IL-4)和白介素-12(IL-12)的影響及療效。方法將支氣管哮喘急性期患者59例隨機分為對照組(29例)和治療組(30例)。對照組採用常規治療,治療組在對照組的基礎上加金水六君煎加減治療。入院時和治療1週後空腹採上肢靜脈血3 ml,抗凝,測定血清IL-4和IL-12濃度,併比較兩組臨床療效。結果治療組治愈9例(30.0%)、顯效20例(66.7%)、無效1例(3.3%),對照組治愈5例(17.2%)、顯效20例(69.0%)、無效4例(13.8%),兩組比較差異有統計學意義(P<0.05)。與治療前比較,治療1週後兩組患者血清IL-4濃度均降低,IL-12濃度均升高(P<0.05)；治療1週後,治療組血清IL-4濃度低于對照組,IL-12濃度高于對照組(P<0.05)。結論金水六君煎加減能協同西藥調節哮喘患者血液中炎癥促進因子與炎癥抑製因子平衡失調,抑製炎癥反應,提高治療效果,值得臨床推廣。
목적：관찰금수륙군전가감대지기관효천급성기환자혈청백개소-4(IL-4)화백개소-12(IL-12)적영향급료효。방법장지기관효천급성기환자59례수궤분위대조조(29례)화치료조(30례)。대조조채용상규치료,치료조재대조조적기출상가금수륙군전가감치료。입원시화치료1주후공복채상지정맥혈3 ml,항응,측정혈청IL-4화IL-12농도,병비교량조림상료효。결과치료조치유9례(30.0%)、현효20례(66.7%)、무효1례(3.3%),대조조치유5례(17.2%)、현효20례(69.0%)、무효4례(13.8%),량조비교차이유통계학의의(P<0.05)。여치료전비교,치료1주후량조환자혈청IL-4농도균강저,IL-12농도균승고(P<0.05)；치료1주후,치료조혈청IL-4농도저우대조조,IL-12농도고우대조조(P<0.05)。결론금수륙군전가감능협동서약조절효천환자혈액중염증촉진인자여염증억제인자평형실조,억제염증반응,제고치료효과,치득림상추엄。
Objective Effect of serum interleukin-4 ( IL-4 ) and interleukin-12 ( IL-12 ) on bronchial asthma patients in acute phase by Jinshui-six gentleman Decoction and Its curative effect. Methods 59 cases of bronchial asthma in acute phase were randomly divided into the control group (29 cases) and treatment group (30 cases). The control group were conventional treated,and the treatment group added Jinshui-six Decoction on the basis of the control group. At the time of admission and after 1 weeks of treatment, Upper limb vein blood 3 ml were recovered and anticoagulanted to determined IL-4 and IL-12 , compared the clini_cal effect of the two groups. Results The treatment group and the control group cured, markedly effective and ineffective were 9 ( 30%) VS 5 ( 17 . 2%) , 20 ( 66 . 7%) VS 20 ( 69%) and 1 ( 3 . 3%) VS 4 (13. 8%), there was significant difference between the treatment group and the control group. Two groups of IL-4 concentration decreased after treatment, but the concentration of IL-12 in treatment group were in_creased, the amplitude of variation is larger, the two groups before and after treatment and compared, the difference was statistically significant;two groups before and after treatment were compared, the difference had statistical significance. Conclusion Jinshui-six Decoction and Western medicine can collaborative regu_lation of blood in patients with asthma inflammation promoting factors and suppression of inflammation factor balance, inhibit inflammatory reaction, enhance the treatment effect, is worth the clinical promotion.
