湘南学院学报（医学版）
湘南學院學報（醫學版）
상남학원학보（의학판）
JOURNAL OF XIANGNAN UNIVERSITY(MEDICAL SCIENCES)
2014年
4期
1-5
,共5页
张伟%李晓杰%徐香云%罗利香%陈秋冬
張偉%李曉傑%徐香雲%囉利香%陳鞦鼕
장위%리효걸%서향운%라리향%진추동
肺鳞癌%碱性成纤维细胞生长因子%成纤维生长因子受体1
肺鱗癌%堿性成纖維細胞生長因子%成纖維生長因子受體1
폐린암%감성성섬유세포생장인자%성섬유생장인자수체1
Squamous-cell lung cancer%Basic fibroblast growth factor(bFGF)%Fibroblast growth factor receptors1(FGFR1 )
目的：探讨碱性成纤维细胞生长因子(fibroblast growth factor,bFGF)及成纤维生长因子受体1(fibroblast growth factor receptors,FGFR1)在肺鳞癌组织中的表达及临床意义,并分析bFGF与FGFR1两者表达之间的联系。方法用免疫组织化学方法( Ultra Sensitive SP法)检测136例肺鳞癌和115例正常肺组织中bFGF、FGFR1的表达。通过单因素分析对9项潜在的可能影响肺鳞癌组织中bFGF、FGFR1表达的临床病理因素进行统计学分析。结果 bFGF、FG_FR1在正常肺组织中均不表达；肺鳞癌组织中bFGF、FGFR1的阳性表达率分别为72.06%和80.15%,与正常肺组织比较差异有统计学意义(P<0.05)。 bFGF、FGFR1两者共同阳性表达率为52.94%,其表达阳性程度呈显著正相关(P<0.05)。 bFGF表达与肺癌分化程度、淋巴结癌转移、血管浸润和远处器官癌转移有关(P<0.05),FGFR1表达与肺癌分化程度、淋巴结癌转移、TNM分期、血管浸润和远处器官癌转移有关(P<0.05)。结论联合检测bFGF、FGFR1有助于肺癌病理分级、分期和预后判断。 bFGF、FGFR1可作为肺癌早期诊断、判定恶性程度和判断预后的新指标。
目的：探討堿性成纖維細胞生長因子(fibroblast growth factor,bFGF)及成纖維生長因子受體1(fibroblast growth factor receptors,FGFR1)在肺鱗癌組織中的錶達及臨床意義,併分析bFGF與FGFR1兩者錶達之間的聯繫。方法用免疫組織化學方法( Ultra Sensitive SP法)檢測136例肺鱗癌和115例正常肺組織中bFGF、FGFR1的錶達。通過單因素分析對9項潛在的可能影響肺鱗癌組織中bFGF、FGFR1錶達的臨床病理因素進行統計學分析。結果 bFGF、FG_FR1在正常肺組織中均不錶達；肺鱗癌組織中bFGF、FGFR1的暘性錶達率分彆為72.06%和80.15%,與正常肺組織比較差異有統計學意義(P<0.05)。 bFGF、FGFR1兩者共同暘性錶達率為52.94%,其錶達暘性程度呈顯著正相關(P<0.05)。 bFGF錶達與肺癌分化程度、淋巴結癌轉移、血管浸潤和遠處器官癌轉移有關(P<0.05),FGFR1錶達與肺癌分化程度、淋巴結癌轉移、TNM分期、血管浸潤和遠處器官癌轉移有關(P<0.05)。結論聯閤檢測bFGF、FGFR1有助于肺癌病理分級、分期和預後判斷。 bFGF、FGFR1可作為肺癌早期診斷、判定噁性程度和判斷預後的新指標。
목적：탐토감성성섬유세포생장인자(fibroblast growth factor,bFGF)급성섬유생장인자수체1(fibroblast growth factor receptors,FGFR1)재폐린암조직중적표체급림상의의,병분석bFGF여FGFR1량자표체지간적련계。방법용면역조직화학방법( Ultra Sensitive SP법)검측136례폐린암화115례정상폐조직중bFGF、FGFR1적표체。통과단인소분석대9항잠재적가능영향폐린암조직중bFGF、FGFR1표체적림상병리인소진행통계학분석。결과 bFGF、FG_FR1재정상폐조직중균불표체；폐린암조직중bFGF、FGFR1적양성표체솔분별위72.06%화80.15%,여정상폐조직비교차이유통계학의의(P<0.05)。 bFGF、FGFR1량자공동양성표체솔위52.94%,기표체양성정도정현저정상관(P<0.05)。 bFGF표체여폐암분화정도、림파결암전이、혈관침윤화원처기관암전이유관(P<0.05),FGFR1표체여폐암분화정도、림파결암전이、TNM분기、혈관침윤화원처기관암전이유관(P<0.05)。결론연합검측bFGF、FGFR1유조우폐암병리분급、분기화예후판단。 bFGF、FGFR1가작위폐암조기진단、판정악성정도화판단예후적신지표。
Objective To investigate the expression of bFGF and FGFR1 in squamous-cell lung cancer (SCLC) and its significance, analyze the correlation between bFGF and FGFR1. Methods The expression of bFGF and FGFR1 was detected by Ultra Senstive SP method in 136 cases of SCLC and 115 cases of normal Lung tissue samples. Nine potential clinicopathological factors influencing the expression of bFGF and FGFR1 in SCLC were assessed by univariate analysis. Results No expression of bFGF and FGFR1 was detectable in normal lung tissues. The positive rate of the bFGF and FGFR1 expression was 72. 06 % and 80. 15 % in SCLC. The Common expression rate of bFGF and FGFR1 was 52. 94% in SCLC,and there was a positive correlation between the positive expression of bFGF and FGF1 ( P<0 . 05 ) . The expression of bFGF is in con_nection with differentiation, lymphaden metastasis, vascular invasion and distant organ metastasis ( P<0. 05). The expression of FGFR1 is connected with differentiation, lymphaden metastasis, TNM-staging, vascular invasion and distant organ metastasis(P<0. 05). Conclusion Combined detection of bFGF and FG_FR1 is helpful to the pathological grading,staging and the judgment of prognosis. It suggests that bFGF and FGFR1 may become a new target for early diagnosis,the determination of malignant degree and prognosis e_valuation of SCLC.
