CAJ | 학술논문

目的：评价高强度聚焦超声（ HIFU）精确定位消融治疗子宫肌瘤的临床效果。方法：对52例（87个肌瘤）子宫肌瘤患者，采用JC型聚焦超声肿瘤治疗系统在超声精确定位和实时监控下对靶肌瘤进行消融治疗。治疗1个月内以增强MRI观察靶肌瘤的消融率；治疗后6个月、12个月以平扫MRI评价靶肌瘤的缩小率，并随访患者月经量和血红蛋白的变化。结果：治疗1个月内靶肌瘤消融率为（83.2±13.6）％，治疗后6个月、12个月靶肌瘤体积明显缩小，与治疗前比较差异有显著性（ P均＜0.05），靶肌瘤缩小率分别为（56.04±23.65）％和（70.00±21.26）％。治疗后6个月、12个月患者月经周期缩短，月经量减少，血液血红蛋白（ Hb）升高。治疗中及治疗后无严重并发症。结论：镇静镇痛下高强度聚焦超声精确定位消融治疗子宫肌瘤安全有效。
목적：평개고강도취초초성（ HIFU）정학정위소융치료자궁기류적림상효과。방법：대52례（87개기류）자궁기류환자，채용JC형취초초성종류치료계통재초성정학정위화실시감공하대파기류진행소융치료。치료1개월내이증강MRI관찰파기류적소융솔；치료후6개월、12개월이평소MRI평개파기류적축소솔，병수방환자월경량화혈홍단백적변화。결과：치료1개월내파기류소융솔위（83.2±13.6）％，치료후6개월、12개월파기류체적명현축소，여치료전비교차이유현저성（ P균＜0.05），파기류축소솔분별위（56.04±23.65）％화（70.00±21.26）％。치료후6개월、12개월환자월경주기축단，월경량감소，혈액혈홍단백（ Hb）승고。치료중급치료후무엄중병발증。결론：진정진통하고강도취초초성정학정위소융치료자궁기류안전유효。
Objective:To evaluate the clinical efficacy and safety of high-intensity focused ultrasound ( HIFU) by precise positioning for ablation of hyste-romyoma.Methods:By precise positioning and applying real-time monitoring system(JC-type),52 patients with hysteromyoma (87 myomas) underwent ablation at the location of the focal field.One month after treatment,enhanced MRI was performed to determine the ablation rate for the target fibroids,and plain MRI was applied to evaluate the focal size reduction 6 months and 12 months after invention,respectively.The patients were also followed up for the changes of the menstruation and hemoglobin level.Results:The ablation rate of target fibroids was (83.2 ±13.6)% within one month after treatment.Six months and twelve months after treatment,the size of target fibroids was significantly reduced[(56.04 ±23.65)%;(70.00 ±21.26)%,respectively], and the menstrual blood volume was reduced,whereas hemoglobin level was elevated.The difference was significant(all P <0.05).No serious intra-or post-operative complications occurred.Conclusion:Under sedation analgesia,high-focused ultrasound by precise positioning for ablation of the hysteromyo-ma can be safe and efficacious.