皖南医学院学报
皖南醫學院學報
환남의학원학보
ACTA ACADEMIAE MEDICINAE WANNAN
2014年
6期
483-485
,共3页
多发性骨髓瘤%TAp63%β2MG
多髮性骨髓瘤%TAp63%β2MG
다발성골수류%TAp63%β2MG
multiple myeloma%TAp63%β2 MG
目的：探讨TAp63 mRNA在多发性骨髓瘤（ MM）中的表达及其在MM发病和预后中的可能作用。方法：采用RT-PCR检测19例MM患者骨髓及10例非恶性血液病患者骨髓中TAp63 mRNA的表达水平。结果：TAp63 mRNA在MM患者骨髓及非恶性血液病患者骨髓中平均灰度值分别为0.912±0.424、0.315±0.035，两者比较有显著性差异（P＜0.001）；其中ISS分期Ⅲ期患者的TAp63 mRNA平均灰度值显著高于Ⅰ期及Ⅱ期患者（P=0.000），同时MM患者TAp63 mRNA的表达强度与血清β2MG有显著正相关性（r=0.607，P=0.006）。结论：TAp63基因在MM患者中呈现了高表达状态，参与了MM的发生、发展，并与预后相关。
目的：探討TAp63 mRNA在多髮性骨髓瘤（ MM）中的錶達及其在MM髮病和預後中的可能作用。方法：採用RT-PCR檢測19例MM患者骨髓及10例非噁性血液病患者骨髓中TAp63 mRNA的錶達水平。結果：TAp63 mRNA在MM患者骨髓及非噁性血液病患者骨髓中平均灰度值分彆為0.912±0.424、0.315±0.035，兩者比較有顯著性差異（P＜0.001）；其中ISS分期Ⅲ期患者的TAp63 mRNA平均灰度值顯著高于Ⅰ期及Ⅱ期患者（P=0.000），同時MM患者TAp63 mRNA的錶達彊度與血清β2MG有顯著正相關性（r=0.607，P=0.006）。結論：TAp63基因在MM患者中呈現瞭高錶達狀態，參與瞭MM的髮生、髮展，併與預後相關。
목적：탐토TAp63 mRNA재다발성골수류（ MM）중적표체급기재MM발병화예후중적가능작용。방법：채용RT-PCR검측19례MM환자골수급10례비악성혈액병환자골수중TAp63 mRNA적표체수평。결과：TAp63 mRNA재MM환자골수급비악성혈액병환자골수중평균회도치분별위0.912±0.424、0.315±0.035，량자비교유현저성차이（P＜0.001）；기중ISS분기Ⅲ기환자적TAp63 mRNA평균회도치현저고우Ⅰ기급Ⅱ기환자（P=0.000），동시MM환자TAp63 mRNA적표체강도여혈청β2MG유현저정상관성（r=0.607，P=0.006）。결론：TAp63기인재MM환자중정현료고표체상태，삼여료MM적발생、발전，병여예후상관。
Objective:To investigate the expression of TAp63 mRNA in multiple myeloma ( MM) and its potential role in pathogenesis and prognosis. Methods:Reverse transcription polymerase chain reaction(RT-PCR) was used to determine the marrow level of TAp63 mRNA in 19 patients with MM and another 10 of hematologic non-malignancies.Results:TAp63 mRNA expression level was 0.912 ±0.424 for the MM patients and 0.315 ±0.035 for the hematologic non-malignancies.The two groups were significantly different(P<0.001).By the International Staging System(ISS) for multiple myeloma, the mean level of TAp63 mRNA in patients at stage Ⅲ was significantly higher than those at stage Ⅰ and Ⅱ(P=0.000),and the TAp63 mRNA expres-sion was positively related to serum β2MG in MM patients(r=0.607;P=0.607).Conclusion:TAp63 presents a higher expression in patients with MM, suggesting that this gene is involved in the occurrence and development of MM ,and may be an indicator to estimate the prognosis .
