CAJ | 학술논문

冠状动脉粥样硬化（ coronary Atherosclerosis ， CAS）是动脉粥样硬化中对人类健康危害最大的一种；白藜芦醇（ resveratrol ， RES）是具有生物学多效性的多酚类物质。大量的细胞和动物及临床试验从不同层面探究了了RES防治CAS的作用机制，通过发挥起自身的生物学多效性效应，干预氧化应激、炎症等细胞因子的表达水平，调节脂质及相关激素在体内的分布，进而抑制血小板聚集、抑制SMC活化增殖迁移、抗氧化、抗炎症反应、扩血管抗CAS；RES对CAS的作用机制逐渐明确，但其分子及细胞水平的机制体现与临床疗效上的差异也提醒我们反思，文中就RES对CAS的作用机制作一综述。
관상동맥죽양경화（ coronary Atherosclerosis ， CAS）시동맥죽양경화중대인류건강위해최대적일충；백려호순（ resveratrol ， RES）시구유생물학다효성적다분류물질。대량적세포화동물급림상시험종불동층면탐구료료RES방치CAS적작용궤제，통과발휘기자신적생물학다효성효응，간예양화응격、염증등세포인자적표체수평，조절지질급상관격소재체내적분포，진이억제혈소판취집、억제SMC활화증식천이、항양화、항염증반응、확혈관항CAS；RES대CAS적작용궤제축점명학，단기분자급세포수평적궤제체현여림상료효상적차이야제성아문반사，문중취RES대CAS적작용궤제작일종술。
Coronary atherosclerosis , the principal cause of death in atherosclerosis , and the cardiovascular protective proper-ties of RES, a polyphenol compounds , have been explained by a substantial body of evidence in cell , animal and clinical research . Which through it′s biological pleiotropy , inhibit oxidative stress , reduce cytokines , then activate the inhibition of platelets aggregation , anti-proliferation, anti-oxidant, anti-inflammatory and vasodilatation .However, the discrepancy between laboratory and clinical call for further investigation .The review will summarize the novel mechanisms of RES on CAS .