CAJ | 학술논문

目的：体脂量和肥胖相关（ fat mass and obesity associated ， FTO）基因与体质指数增加以及过多能量摄入相关。文中探讨FTO基因多态性与环境因素的交互作用对哈萨克族学龄儿童肥胖的影响。方法从“伊犁哈萨克自治州哈萨克族学龄儿童超重肥胖调查”中选择279名6～13岁小学生，根据中国肥胖问题工作组提出的《中国学龄儿童青少年超重、肥胖筛查体质指数值分类标准》中不同年龄、性别的BMI判定，分为肥胖组（141名）和正常组（138名），进行体格检查、问卷调查以及FTO基因rs9939609多态性检测。结果采用主成分方法进行探索性因子分析，共提取不良饮食习惯、食欲状况、户外活动、挑食情况、活动方式和睡眠时间6个因子。 Logistic回归分析显示，FTO基因rs9939609与食欲状况、户外活动的交互作用归因百分依次为76．49％、79．95％。结论在哈萨克族学龄儿童中，食欲状况、户外活动可能修饰FTO基因与肥胖的关系，但需要进一步前瞻性的干预性研究证实该种影响作用。
목적：체지량화비반상관（ fat mass and obesity associated ， FTO）기인여체질지수증가이급과다능량섭입상관。문중탐토FTO기인다태성여배경인소적교호작용대합살극족학령인동비반적영향。방법종“이리합살극자치주합살극족학령인동초중비반조사”중선택279명6～13세소학생，근거중국비반문제공작조제출적《중국학령인동청소년초중、비반사사체질지수치분류표준》중불동년령、성별적BMI판정，분위비반조（141명）화정상조（138명），진행체격검사、문권조사이급FTO기인rs9939609다태성검측。결과채용주성분방법진행탐색성인자분석，공제취불량음식습관、식욕상황、호외활동、도식정황、활동방식화수면시간6개인자。 Logistic회귀분석현시，FTO기인rs9939609여식욕상황、호외활동적교호작용귀인백분의차위76．49％、79．95％。결론재합살극족학령인동중，식욕상황、호외활동가능수식FTO기인여비반적관계，단수요진일보전첨성적간예성연구증실해충영향작용。
Objective The fat mass-and obesity-associated (FTO) gene is related to increased body mass index (BMI) and elevated energy intake .This study explored the contribution of the interaction between FTO gene polymorphism and 1ife style to the risk of obesity in the Kazakh schoolchildren . Methods A total of 279 Kazakh schoolchildren aged 6-13 years were selected from Yili Ka-zakh Child Obesity Study and divided into an obesity group (n=141) and a normal weight group (n=138) based on the BMI cutoffs rec-ommended by the Chinese Working Group on Obesity for Children .The children were subjected to anthropometric measurement , question-naire investigation , and determination of the rs9939609 polymorphism of the FTO gene. Results Six risk factors of obesity were extrac-ted by factor analysis, including harmful eating habits, appetite status, outdoor activities, fussiness about food, activity mode, and hours of sleep.Logistic regression analysis showed that the interaction between rs 9939609 polymorphism and appetite status constituted an obe-sity risk of 76.49%, and that between rs9939609 polymorphism and outdoor activities constituted an obesity risk of 79.95%. Conclusion Appetite status and outdoor activities might modify the relationship of the FTO gene with the risk of obesity in Kazakh school-children.However, further prospective interventions are needed verify the influence of the interaction between the FTO gene and life style on the risk of obesity.