CAJ | 학술논문

目的：观察炔雌醇环丙孕酮（达英-35）联合二甲双胍治疗多囊卵巢综合征的临床效果。方法：52例多囊卵巢综合征患者按照入院顺序分为观察组和对照组，每组26例。观察组采用达英-35联合二甲双胍治疗，对照组采用达英-35治疗，比较两组的疗效。结果：两组治疗后黄体生成激素（ LH）、睾酮（ T）性激素水平均较治疗前改善明显，观察组治疗后LH、T水平较对照组明显降低，差异有统计学意义（ p<0.05）。观察组空腹血糖（ FBG）水平治疗后与其治疗前及对照组比较，差异均有统计学意义（ p<0.05）。结论：达英-35联合二甲双胍治疗pCOS临床效果优于单用达英-35，临床疗效确切，且服用方便。
목적：관찰결자순배병잉동（체영-35）연합이갑쌍고치료다낭란소종합정적림상효과。방법：52례다낭란소종합정환자안조입원순서분위관찰조화대조조，매조26례。관찰조채용체영-35연합이갑쌍고치료，대조조채용체영-35치료，비교량조적료효。결과：량조치료후황체생성격소（ LH）、고동（ T）성격소수평균교치료전개선명현，관찰조치료후LH、T수평교대조조명현강저，차이유통계학의의（ p<0.05）。관찰조공복혈당（ FBG）수평치료후여기치료전급대조조비교，차이균유통계학의의（ p<0.05）。결론：체영-35연합이갑쌍고치료pCOS림상효과우우단용체영-35，림상료효학절，차복용방편。
Objective:To explore the clinical efficacy of ethinylestradiol and cyproterone acetate( Diane-35 )combined with meformin in the treatment of the patients with polycystic ovary syndrome( pCOS). Methods:Fifty-two patients with pCOS were divided into control group and observation group by hospitalizing order with 26 cases each. patients in the ob-servation group were given Diane-35 combined with metformin while patients in the control group were given Diane-35 on-ly in their treatment. And then the curative effects of the two groups were compared. Results:After treatment,the hirsut-ism of the two groups was obviously reduced,and the acne was improved to different degrees;the luteinizing hormone ( LH)and testosterone( T)sex hormone levels in both of the two groups were obviously improved;the LH of the observa-tion group was significantly lowered than the control group;the T level of the observation group was lower than that of the control group. There was statistical difference in the comparison between the two groups(p<0. 05). After treatment, when the fasting blood-glucose( FBG)level of the observation group was compared with that of the control group and be-fore treatment,there was statistical difference in all the comparison(p<0. 05). Conclusion:The clinical effect of Diane-35 combined with metformin in patients with pCOS is better than Diane-35 only. The definite clinic effect and easy taking make it worthy of clinical diffusion and application.