CAJ | 학술논문

目的：布-加综合征（Budd-Chiari syndrome， BCS）的血流动力学机制是近年来的研究热点。本研究应用计算流体力学（ computational fluid dynamics ， CFD）方法对BCS患者的下腔静脉进行三维数值模拟，探讨其血流动力学特性。方法采用Ansys软件对布-加综合征患者的MR图像进行三维重建，构建下腔静脉个体化三维模型；利用计算流体力学方法对该模型进行数值模拟计算。结果精确仿真下腔静脉三维流体模型，在功能上该模型成功演示了布-加综合征患者下腔静脉血流动力学环境变化过程。病变区域上方有涡流产生；冠状面模拟显示狭窄处血流流速急升高；在狭窄端入口处至最狭窄处静压值逐渐下降，至狭窄处出口处最低；狭窄处的壁面切应力值达到最大。结论该特征性三维血流动力学模型能真实的进行体外模拟布-加综合征的血流动力学特征，血流动力学参量分析结果符合临床实际，有助于进一步研究下腔静脉血管形态病变与复杂血流动力学参数之间的相关性。
목적：포-가종합정（Budd-Chiari syndrome， BCS）적혈류동역학궤제시근년래적연구열점。본연구응용계산류체역학（ computational fluid dynamics ， CFD）방법대BCS환자적하강정맥진행삼유수치모의，탐토기혈류동역학특성。방법채용Ansys연건대포-가종합정환자적MR도상진행삼유중건，구건하강정맥개체화삼유모형；이용계산류체역학방법대해모형진행수치모의계산。결과정학방진하강정맥삼유류체모형，재공능상해모형성공연시료포-가종합정환자하강정맥혈류동역학배경변화과정。병변구역상방유와유산생；관상면모의현시협착처혈류류속급승고；재협착단입구처지최협착처정압치축점하강，지협착처출구처최저；협착처적벽면절응력치체도최대。결론해특정성삼유혈류동역학모형능진실적진행체외모의포-가종합정적혈류동역학특정，혈류동역학삼량분석결과부합림상실제，유조우진일보연구하강정맥혈관형태병변여복잡혈류동역학삼수지간적상관성。
Objective The hemodynamic mechanism of Budd-Chiari syndrome ( BCS ) has become the research hotspot in recent years.The aim of this study was to discuss the hemodynamic characteristics of BCS through 3D numerical simulation for inferior vena cava stenosis based on the fluid dynamics ( CFD) method. Methods 3D model was established from a patient with Budd-Chiari syndrome based on MR image with Ansys software .The numerical simulation of this model was performed by the CFD . Results The 3D model of inferior vena cava functionally demonstrated the change procedure of hemodynamic characteristics of BCS .Vortex was found above the narrow area , and blood flow velocity achieved maximum in the center of the stenosis throughout the coronal section graph.The static pressure value gradually declined at the narrow area entrance to the narrowest place , and achieved minimum value at the exit.The maximum wall shear stress existed in the stenosis . Conclusion Specific 3D computational hemodynamic model can show the hemodynamic characteristics of BCS , and its hemodynamic parameters could be used for clinical practice .It will facilitate the study on correlation of complex hemodynamic parameters and morphology changes of inferior vena cava vascular .