CAJ | 학술논문

衰老作为一种复杂的生命过程，在此过程中有多种因素参与并发挥作用。主要包括体内信号通路中某个因子的基因突变（包括胰岛素信号通路、Wnt信号通路等）、转录调节因子的异常调节作用、染色体发生异常、以及外界环境的改变等。外界因素对衰老的影响作用往往是通过改变染色体状态而实现的。而这种染色体状态的改变是由于生理条件的改变、环境刺激，或者在某些病理状态的诱发下发生的。相比于单纯的基因突和转录因子的异常调节，这种染色体状态改变所引起的基因水平的改变在机体内的持续状态更加持久、更加稳定，并且可以遗传至下一代。因此目前对于衰老的研究更多的关注于这种基因表达水平的变化，特别是表观遗传学对衰老过程中基因表达的调控作用。本文就其相关研究进展作一综述。
쇠로작위일충복잡적생명과정，재차과정중유다충인소삼여병발휘작용。주요포괄체내신호통로중모개인자적기인돌변（포괄이도소신호통로、Wnt신호통로등）、전록조절인자적이상조절작용、염색체발생이상、이급외계배경적개변등。외계인소대쇠로적영향작용왕왕시통과개변염색체상태이실현적。이저충염색체상태적개변시유우생리조건적개변、배경자격，혹자재모사병리상태적유발하발생적。상비우단순적기인돌화전록인자적이상조절，저충염색체상태개변소인기적기인수평적개변재궤체내적지속상태경가지구、경가은정，병차가이유전지하일대。인차목전대우쇠로적연구경다적관주우저충기인표체수평적변화，특별시표관유전학대쇠로과정중기인표체적조공작용。본문취기상관연구진전작일종술。
Aging is caused by a variety of factors, such as gene mutations in signaling pathways ( including insulin signaling pathway and WNT signaling pathways, etc.) , abnormal regulation of transcription factor, unusual chromosome and the change of external environment factors.Effect of environmental factors on aging is often accom-plished by changing chromosome state.The chromosome change is due to the change of physiological conditions, envi-ronmental stimuli, or some pathologic conditions.Compared to simple genetic mutations and abnormal regulation of transcription factors, the chromosome change is more persistent and more sustainable in the body, and can be inherited to the next generation.At present more attention is paid to the change of the gene expression level in the study of ag-ing.This paper reviews the progresses of the study on the relationship between epigenetic and aging.