中华骨质疏松和骨矿盐疾病杂志
中華骨質疏鬆和骨礦鹽疾病雜誌
중화골질소송화골광염질병잡지
CHINESE JOURNAL OF OSTEOPOROSIS AND BONE MINERAL RESEARCH
2014年
4期
357-361
,共5页
性激素结合球蛋白%骨质疏松症%骨密度%骨折
性激素結閤毬蛋白%骨質疏鬆癥%骨密度%骨摺
성격소결합구단백%골질소송증%골밀도%골절
sex hormone-binding globulin%osteoporosis%bone mineral density%fracture
性激素结合球蛋白（SHBG）是由肝脏合成分泌的一种糖蛋白，通过与类固醇激素（特别是雌激素和雄激素）结合发挥影响性激素生物利用度的效应。血清SHBG水平改变与包括骨质疏松症在内的多种疾病有关。骨质疏松症是一种遗传与环境因素相互作用的复杂疾病，近年发现血清SHBG水平升高与骨质疏松症或骨折密切相关，本文就血清SHBG水平与骨质疏松症的关系作一综述。
性激素結閤毬蛋白（SHBG）是由肝髒閤成分泌的一種糖蛋白，通過與類固醇激素（特彆是雌激素和雄激素）結閤髮揮影響性激素生物利用度的效應。血清SHBG水平改變與包括骨質疏鬆癥在內的多種疾病有關。骨質疏鬆癥是一種遺傳與環境因素相互作用的複雜疾病，近年髮現血清SHBG水平升高與骨質疏鬆癥或骨摺密切相關，本文就血清SHBG水平與骨質疏鬆癥的關繫作一綜述。
성격소결합구단백（SHBG）시유간장합성분비적일충당단백，통과여류고순격소（특별시자격소화웅격소）결합발휘영향성격소생물이용도적효응。혈청SHBG수평개변여포괄골질소송증재내적다충질병유관。골질소송증시일충유전여배경인소상호작용적복잡질병，근년발현혈청SHBG수평승고여골질소송증혹골절밀절상관，본문취혈청SHBG수평여골질소송증적관계작일종술。
Sex hormone-binding globulin ( SHBG) is a glycoprotein that is produced and released by the liver . SHBG binds with high affinity to sex steroids ( especially estradiol and androgen ) , thereby regulates their bioavailability and access to target cells .SHBG is involved in many diseases , including osteoporosis , according to the researches .Oste-oporosis is a complex disease which is affected by gene and surroundings .Several resent studies have shown close relation-ship between high level of SHBG and osteoporosis or fracture .Therefore, This review is to illustrate the relationship be-tween them.
