CAJ | 학술논문

目的：探讨手足口病（HFMD）患儿血尿酸（SUA）水平变化及机制。方法选择2014年3月至2014年4月于平顶山市第一人民医院住院治疗的68例 HFMD 患儿为观察组，以同一地区年龄、性别、生活习惯与HFMD患儿相近的68例健康儿童为对照组。检测两组患儿的SUA、血钠、血钾、血糖、尿素氮（BUN）、血肌酐（SCr）并计算血浆渗透压、BUN／SCr比值。结果 HFMD观察组 SUA、BUN、BUN／SCr比值均升高，与对照组相比差异有统计学意义（P＜0．05）；HFMD 组血钠、血钾、血糖、SCr水平与对照组相比无统计学差异。结论 HFMD 患儿的SUA水平增高，其机制可能与肾小球滤过功能减退相关。
목적：탐토수족구병（HFMD）환인혈뇨산（SUA）수평변화급궤제。방법선택2014년3월지2014년4월우평정산시제일인민의원주원치료적68례 HFMD 환인위관찰조，이동일지구년령、성별、생활습관여HFMD환인상근적68례건강인동위대조조。검측량조환인적SUA、혈납、혈갑、혈당、뇨소담（BUN）、혈기항（SCr）병계산혈장삼투압、BUN／SCr비치。결과 HFMD관찰조 SUA、BUN、BUN／SCr비치균승고，여대조조상비차이유통계학의의（P＜0．05）；HFMD 조혈납、혈갑、혈당、SCr수평여대조조상비무통계학차이。결론 HFMD 환인적SUA수평증고，기궤제가능여신소구려과공능감퇴상관。
Objective To investigate the changes of serum uric acid contents in children with hand foot and mouth disease and the possible mechanism. Methods Totally 68 children with hand foot and mouth disease who receivied medical service in the First People’s Hospital of Pingdingshan City from March 2014 to April 2014 were chosed as trial group,and 68 healthy children whose age,sex,living habits were the same as the patients were enrolled as the controls.The contents of serum uric acid,serum sodium,serum potassium, blood glucose,BUN,SCr,plasma osmotic pressure and the ratio of BUN to Scr in the two groups were examined and compared. Results The levels of serum uric acid,BUN and the ratio of BUN to Scr was higher in children with hand foot and mouth disease than in normal children,there was significant difference between the two groups(P <0.05 ).The levels of serum sodium,serum potassium,blood glucose,SCr and plasma osmotic pressure was no significant difference between the two groups(P>0.05 ). Conclusion The levels of serum uric acid is higher in children with hand foot and mouth disease than in normal children and its mechanism may be associated with glomerular filtration dysfunction.