CAJ | 학술논문

目的：研究胃癌患者行胃癌根治术前后血清胃泌素（GAS）、胃动素（MTL）的变化情况。方法选取30例健康志愿者（对照组）和30例限期胃癌根治术患者（胃癌组）为研究对象，采用 ELISA 法检测两组患者术前、术后第1天、第7天空腹血清 GAS和MTL水平。结果胃癌组患者术前血清 GAS 和 MTL 水平明显高于对照组（P＜0．01）；胃癌根治术后第1天胃癌患者的血清GAS和MTL水平较术前明显下降（P＜0.01），并于术后第7天恢复到术前水平。结论胃癌患者的血清胃泌素和胃动素水平在胃癌根治术后可出现一过性降低，胃癌根治术导致的胃动素及胃泌素水平的改变可能是影响胃癌患者术后胃肠动力下降的因素。
목적：연구위암환자행위암근치술전후혈청위비소（GAS）、위동소（MTL）적변화정황。방법선취30례건강지원자（대조조）화30례한기위암근치술환자（위암조）위연구대상，채용 ELISA 법검측량조환자술전、술후제1천、제7천공복혈청 GAS화MTL수평。결과위암조환자술전혈청 GAS 화 MTL 수평명현고우대조조（P＜0．01）；위암근치술후제1천위암환자적혈청GAS화MTL수평교술전명현하강（P＜0.01），병우술후제7천회복도술전수평。결론위암환자적혈청위비소화위동소수평재위암근치술후가출현일과성강저，위암근치술도치적위동소급위비소수평적개변가능시영향위암환자술후위장동력하강적인소。
Objective To study gastric cancer patients with gastric cancer radical operation changes of serum gastrin,motilin before and after operation. Methods 30 healthy volunteers (control group)and 30 cases of gastric cancer patients who were waiting for operation (Cancer Group)as the research object,ELISA method was used to detect the patients of gastric cancer group and control group before and after first days, seventh day of stomach serum GAS and serum MTL level. Results In gastric cancer patients, preoperative serum GAS and MTL levels were significantly higher than that of the control group (P<0.01). After first day of gastric cancer patients serum GAS and MTL levels were significantly decreased in radical resection of gastric cancer (P <0.01 ),and returned to the preoperative level at the seventh day after operation. Conclusion The serum gastrin and motilin levels in serum of gastric cancer patients has a transient decrease in radical gastrectomy for gastric cancer after radical operation of motilin and gastrin levels lead to gastric cancer change may be the factors influence decreased gastrointestinal motility in patients with gastric cancer after operation.