CAJ | 학술논문

目的：探讨急性冠脉综合征（ACS）患者血清正五聚蛋白（PTX-3）和高敏C反应蛋白（hs-CRP）水平变化及其与预后的关联。方法选自2012年4月至2013年4月吴忠市新区医院心内科临床诊断为冠状动脉粥样硬化性心脏病（冠心病）的患者132例，男性81例，女性51例，年龄范围40~75岁，分为稳定型心绞痛35例（SAP组），不稳定型心绞痛患者36例（UAP组），非ST段抬高型心肌梗死患者共32例（NSTEMI组），急性ST段抬高型心肌梗死患者29例（STEMI组）。另选同期年龄、性别相匹的正常体检者共35例（正常对照组）。检测PTX-3、hs-CRP水平，并随访1年主要心血管事件（MACE）的发生情况。结果与对照组比较，UAP组、NSTEMI组和STEMI组患者PTX-3、hs-CRP水平升高，差异具有统计学意义（P均＜0.05）。对97例ACS患者随访1年MACE的发生情况，33例发生MACE。通过ROC曲线计算血浆PTX-3、hs-CRP预测ACS患者发生MACE的最佳界值（cut off value）分别为PTX-3=6.05μg/L，hs-CRP=8.21 mg/L，ROC曲线下面积为0.78、0.58。结论 PTX-3水平能够预测ACS患者MACE发生情况。
목적：탐토급성관맥종합정（ACS）환자혈청정오취단백（PTX-3）화고민C반응단백（hs-CRP）수평변화급기여예후적관련。방법선자2012년4월지2013년4월오충시신구의원심내과림상진단위관상동맥죽양경화성심장병（관심병）적환자132례，남성81례，녀성51례，년령범위40~75세，분위은정형심교통35례（SAP조），불은정형심교통환자36례（UAP조），비ST단태고형심기경사환자공32례（NSTEMI조），급성ST단태고형심기경사환자29례（STEMI조）。령선동기년령、성별상필적정상체검자공35례（정상대조조）。검측PTX-3、hs-CRP수평，병수방1년주요심혈관사건（MACE）적발생정황。결과여대조조비교，UAP조、NSTEMI조화STEMI조환자PTX-3、hs-CRP수평승고，차이구유통계학의의（P균＜0.05）。대97례ACS환자수방1년MACE적발생정황，33례발생MACE。통과ROC곡선계산혈장PTX-3、hs-CRP예측ACS환자발생MACE적최가계치（cut off value）분별위PTX-3=6.05μg/L，hs-CRP=8.21 mg/L，ROC곡선하면적위0.78、0.58。결론 PTX-3수평능구예측ACS환자MACE발생정황。
Objective To discuss the changes of serum pentraxins (PTX-3) and high-sensitivity C-reactive protein (hs-CRP), and correlation between them and prognosis in patients with acute coronary syndrome (ACS). Methods The patients (n=132, male 81, female 51, aged from 40 to 75) were divided into stable angina pectoris group (SAP group,n=35), unstable AP group (UAP group,n=36), non- ST-segment elevation myocardial infarction (NSTEMI group,n=32) and STEMI group (n=29), and other 35 cases of normal physical examinations with same age and sex were chosen as control group. The levels of PTX-3 and hs-CRP were detected, and all patients were followed up for 1 y for observing major adverse cardiovascular events (MACE).Results Compared with control group, the levels of PTX-3 and hs-CRP increased in UAP group, NSTEMI group STEMI group (allP<0.05). There were 33 cases had MACE after followed up for 1 y in 97 ACS patients. The cut-off value of PTX-3 or hs-CRP for predicting MACE calculated with ROC curve was, respectively, PTX-3=6.05μg/L and hs-CRP=8.21 mg/L, and area under ROC curve was, respectively, 0.78 and 0.58.Conclusion The level of PTX-3 can predict the incidence of MACE in ACS patients.