CAJ | 학술논문

目的：探讨冠心病患者血浆脑钠肽（BNP ）与冠状动脉病变严重程度及心脏变时性的相关性。方法记录冠心病患者血浆BNP水平及心脏变时性指标，包括rHR和HRR ，并记录冠状动脉造影（CAG ）结果，计算Gensini评分，对比分析无症状性心肌缺血、稳定型心绞痛及不稳定型心绞痛3组患者血浆BNP水平及心脏变时性指标差异。评价血浆BNP水平与冠状动脉病变严重程度及心脏变时性指标相关性。结果本研究共纳入462例冠心病患者，单因素方差分析结果显示各组间BNP水平差异均有统计学意义（均 P＜0.05）；无症状性心肌缺血与不稳定型心绞痛心脏变时性指标rHR比较差异有统计学意义（ P＜0.05）。Person相关分析显示，冠心病患者血浆BNP水平与冠状动脉病变Gensini评分呈正相关（r＝0.43，P＜0.05），与心脏变时性指标 rHR及HRR均呈负相关（r＝－0.34，－0.40，均 P＜0.05）。结论冠心病患者血浆BNP与冠状动脉病变程度及心脏变时性指标rHR和HRR密切相关，对于评价冠心病心脏功能的改变有重要的临床价值。
목적：탐토관심병환자혈장뇌납태（BNP ）여관상동맥병변엄중정도급심장변시성적상관성。방법기록관심병환자혈장BNP수평급심장변시성지표，포괄rHR화HRR ，병기록관상동맥조영（CAG ）결과，계산Gensini평분，대비분석무증상성심기결혈、은정형심교통급불은정형심교통3조환자혈장BNP수평급심장변시성지표차이。평개혈장BNP수평여관상동맥병변엄중정도급심장변시성지표상관성。결과본연구공납입462례관심병환자，단인소방차분석결과현시각조간BNP수평차이균유통계학의의（균 P＜0.05）；무증상성심기결혈여불은정형심교통심장변시성지표rHR비교차이유통계학의의（ P＜0.05）。Person상관분석현시，관심병환자혈장BNP수평여관상동맥병변Gensini평분정정상관（r＝0.43，P＜0.05），여심장변시성지표 rHR급HRR균정부상관（r＝－0.34，－0.40，균 P＜0.05）。결론관심병환자혈장BNP여관상동맥병변정도급심장변시성지표rHR화HRR밀절상관，대우평개관심병심장공능적개변유중요적림상개치。
Objective To investigate the correlation of degree of coronary artery lesion and chronotropic response in patients with coronary heart disease. Methods BNP and chronotropic response including rHR and HRR were recorded of patients with coronary heart disease ,outcomes of coronary angiography (CAG ) and the score of Gensini were also recorded.Contrastive analysis of BNP and chronotropic response of three groups ,myocardial ischemia ,stable angina pectoris (SAP) and unstable angina pectoris (UAP) ,were taken and the correlation of degree of coronary artery lesion and chronotropic response was evaluated.Results A total of 462 patients with coronary heart disease were enrolled.Analysis of Variance showed there were significant differences of the level of BNP among the three groups (all P<0.05).There were significant differences of rHR between the group of myocardial ischemia and UAP ( P<0.05).There was positive correlation between BNP and the score of Gensini (r=0.43 ,P<0.05).There was negative correlations between BNP and rHR ,so did BNP and HRR (r= -0.34 ,-0.40 ,all P<0.05).Conclusions BNP ,rHR ,HRR ,and degree of coronary artery lesion are closely related and valuable for the evaluation of cardiac function in patients with coronary heart disease.