CAJ | 학술논문

为研究烟碱对小鼠负重游泳时间和抗疲劳相关理化指标的影响，选择SPF昆明种雄性小鼠随机分为4组，试验组每天分别皮下注射尼古丁酒石酸盐（生理盐水配制）0.1 mg/kg、0.5 mg/kg、1.0 mg/kg，对照组每天注射1.0 mg/kg生理盐水，在注射20 d后检测体重、负重游泳时间，以及血尿素氮、血乳酸、肝糖原含量。结果表明，0.5 mg/kg尼古丁酒石酸盐能显著增加小鼠游泳时间，降低血尿素氮和血乳酸浓度，而对肝糖原含量没有影响。小鼠游泳时间的增加可能是因为烟碱刺激小鼠激素的分泌而导致运动能力增强。
위연구연감대소서부중유영시간화항피로상관이화지표적영향，선택SPF곤명충웅성소서수궤분위4조，시험조매천분별피하주사니고정주석산염（생리염수배제）0.1 mg/kg、0.5 mg/kg、1.0 mg/kg，대조조매천주사1.0 mg/kg생리염수，재주사20 d후검측체중、부중유영시간，이급혈뇨소담、혈유산、간당원함량。결과표명，0.5 mg/kg니고정주석산염능현저증가소서유영시간，강저혈뇨소담화혈유산농도，이대간당원함량몰유영향。소서유영시간적증가가능시인위연감자격소서격소적분비이도치운동능력증강。
To investigate the effect of nicotine on mice swimming tine and physical and chemical indicators of fatigue, SPF Kunming male mice were randomly divided into four groups. Experimental groups were injected subcutaneously nicotine tartrate (Formulated with saline) daily at concentrations of 0.1, 0.5, 1.0 mg/kg. Control group was injected with saline at the concentration of 1.0 mg/kg. After 20 days, mice weight were weighed, the swimming time, urea nitrogen, blood lactate and glycogen were measured. The results showed that 0.5 mg/kg nicotine tartrate could increase swimming time significantly, reduce blood urea concentration and blood lactate glycogen concentration significantly, but could not affect the liver glycogen concentration. The mechanism was speculated that nicotine might stimulate the secretion of hormones and enhances activity in mice.