CAJ | 학술논문

糖尿病视网膜病变（ DR）作为糖尿病患者晚期出现严重视力障碍甚至致盲的主要病因之一，也是糖尿病晚期出现全身微血管病变的重要局部表现。它直接导致糖尿病患者晚期生活质量出现严重下降。在现有的研究结果显示，免疫炎症因子作用与DR的产生与进展息息相关，其中以ICAM－1、抗内皮细胞抗体、TNF－α、VEGF、补体、HLA等的作用尤为突出，并一直作为研究热门方向被广泛关注。以下将对相关免疫炎症因子在DR中的作用机制进行综述。
당뇨병시망막병변（ DR）작위당뇨병환자만기출현엄중시력장애심지치맹적주요병인지일，야시당뇨병만기출현전신미혈관병변적중요국부표현。타직접도치당뇨병환자만기생활질량출현엄중하강。재현유적연구결과현시，면역염증인자작용여DR적산생여진전식식상관，기중이ICAM－1、항내피세포항체、TNF－α、VEGF、보체、HLA등적작용우위돌출，병일직작위연구열문방향피엄범관주。이하장대상관면역염증인자재DR중적작용궤제진행종술。
Diabetic retinopathy ( DR) , one of the leading causes that result in serious visual impairment or blind-ness, was part of systemic microvascular complications of diabetes .DR seriously impairs the quality of life in diabetic pa-tients.Recent researches suggested that the development of DR may be associated with inflammatory immune factors such as ICAM-1, endothelial cell antibodies,TNF-α,VEGF,complements,and HLA.The immunological mechanisms of DR have become a heated area of research .The aim of the present review is to provide an overview of immunological mechanisms of DR.