CAJ | 학술논문

子宫内膜异位症的特征是子宫内膜样组织出现在子宫以外部位，其严重影响着患者的生活质量。尽管子宫内膜异位症病因和发病机制不清，但一般认为子宫基底层内膜异位于宫腔以外生长与高雌激素刺激密切相关，并涉及内膜细胞生理、生物化学和分子生物学等机制。 G蛋白耦联受体超家族成员－GPR30是新型雌激素膜受体。近年的基础研究发现其介导的快速效应途径致靶细胞增殖、侵润，在子宫内膜异位症发生发展中起重要作用。该文就近年对GPR30在子宫内膜异位症发病机制中的作用进行解读。
자궁내막이위증적특정시자궁내막양조직출현재자궁이외부위，기엄중영향착환자적생활질량。진관자궁내막이위증병인화발병궤제불청，단일반인위자궁기저층내막이위우궁강이외생장여고자격소자격밀절상관，병섭급내막세포생리、생물화학화분자생물학등궤제。 G단백우련수체초가족성원－GPR30시신형자격소막수체。근년적기출연구발현기개도적쾌속효응도경치파세포증식、침윤，재자궁내막이위증발생발전중기중요작용。해문취근년대GPR30재자궁내막이위증발병궤제중적작용진행해독。
Endometriosis is characterized by endometrial-like tissue outside the uterus , which affects the life quality of patients seriously . Although its exact etiology and pathogenesis are unclear , it has been proposed that the base layer outside the uterus is closely related to the stimulation of high estrogen and involves in the mechanisms of cellular physiology , biochemistry and molecular biology .G protein-coupled receptor 30 (GPR30) is a new type of estrogen receptor.In recent years, researches indicate that the mediating rapid effect plays an important role in the development of endometriosis .In this paper , we summarized the relationship between GPR 30 and the pathogenesis of endometriosis .