CAJ | 학술논문

目的：研究儿童近视进展与减少视网膜中央凹区多焦视网膜电图（ mfERG ）响应的关联。方法2011年1月到2013年12月共计58名受试者来自我科，年龄7～10岁，平均（9．6±0．2）岁。所有受试者初次就诊、再次就诊和随访1年时接受眼科检查。眼科检查包括客观和主观折射，轴向长度测量和mfERG记录。结果儿童近视的增加与轴向长度的增加有关（皮尔森相关， r ＝0．70， P ＜0．001）。1年期间近视进展时在49％和96％的对比不同区域的mfERG响应的变化。随着近视增加，DC振幅在96％之下，DC和IC振幅在49％之下，所有区域的检查值减少。 IC振幅在96％中央环1和2的对比减少，但环3和4的振幅略有增加，IC潜时在两种对比减少。相比之下，DC潜时在环1和2的49％对比增加、环3～5近中心区均降低。 DC潜时在96％对比在所有检查区域略微增加，除了环1。时域来看，在49％对比时，随着近视进展，环1的DC和IC振幅减少（皮尔森相关， r ＝0．50～0．53， P ＜0．01）。时间域来看随着近视的进展，大部分部位的DC和IC潜时检查未受影响，除了49％对比时环3的DC潜时（ r ＝0．54， P ＜0．01）和96％对比时环5的IC潜时（r＝0．49， P ＝0．49）。结论低于10周岁儿童近视进展中，内视网膜功能的中央区和旁中央区恶化。
목적：연구인동근시진전여감소시망막중앙요구다초시망막전도（ mfERG ）향응적관련。방법2011년1월도2013년12월공계58명수시자래자아과，년령7～10세，평균（9．6±0．2）세。소유수시자초차취진、재차취진화수방1년시접수안과검사。안과검사포괄객관화주관절사，축향장도측량화mfERG기록。결과인동근시적증가여축향장도적증가유관（피이삼상관， r ＝0．70， P ＜0．001）。1년기간근시진전시재49％화96％적대비불동구역적mfERG향응적변화。수착근시증가，DC진폭재96％지하，DC화IC진폭재49％지하，소유구역적검사치감소。 IC진폭재96％중앙배1화2적대비감소，단배3화4적진폭략유증가，IC잠시재량충대비감소。상비지하，DC잠시재배1화2적49％대비증가、배3～5근중심구균강저。 DC잠시재96％대비재소유검사구역략미증가，제료배1。시역래간，재49％대비시，수착근시진전，배1적DC화IC진폭감소（피이삼상관， r ＝0．50～0．53， P ＜0．01）。시간역래간수착근시적진전，대부분부위적DC화IC잠시검사미수영향，제료49％대비시배3적DC잠시（ r ＝0．54， P ＜0．01）화96％대비시배5적IC잠시（r＝0．49， P ＝0．49）。결론저우10주세인동근시진전중，내시망막공능적중앙구화방중앙구악화。
Objective To study the relationship between myopia progression and foveal centralis multifocal ERG ( mfERG) response in children .Methods Totally 26 patients who presented to our clinic between January 2011 and De-cember 2013 were enrolled in this study .Average age was 10.6 ±1.2, range from 9 to 13 years.Ophthalmic examinations , including objective and subjective refraction , axial length, and mfERG, were followed for 1 year.Results The progres-sion of myopia related to the increase in axial length (Pearson correlation r =-0.70, P <0.001).Multifocal ERG results showed that DC amplitude was reduced for 96% contrast , and both DC and IC amplitudes were reduced in all fields for 49% contrast.IC amplitude was reduced in ring 1 and ring 2, but slightly increased in ring 3 and ring 4 for 96%contrast. IC latency was shortened for both 49%contrast and 96%contrast , whereas DC latency increased in ring 1 and ring 2 and reduced in ring 3~5 for 49%contrast.DC latency slightly increased in all areas except ring 1 for 96% contrast.In the time domain, the progression of myopia related to the decrease of DC and IC amplitude in ring 1 for 49%contrast (Pearson correlation, r =0.50 ~0.50, P <0.01).DC and IC latencies in most fields were not affected , except DC latency in ring 3 for 49%contrast ( r =0.54, P <0.01) and IC latency in ring 5 ( r =0.49, P =0.49) for 96%contrast.Con-clusion In the children aged lower than 10, myopia progression is associated with decrease of central and paracentral fove-al function .