中国妇幼健康研究
中國婦幼健康研究
중국부유건강연구
CHINESE JOURNAL OF MATERNAL AND CHILD HEALTH RESEARCH
2014年
6期
996-998
,共3页
子痫前期-子痫%胰岛素抵抗%胰岛素敏感指数%瘦素
子癇前期-子癇%胰島素牴抗%胰島素敏感指數%瘦素
자간전기-자간%이도소저항%이도소민감지수%수소
preeclampsia-eclampsia%insulin resistance ( IR)%insulin sensitivity index ( ISI)%leptin
目的：探讨子痫前期－子痫时胰岛素抵抗与血清瘦素水平的关系。方法选取子痫前期－子痫时患者36例为研究组，其中子痫前期轻度20例，重度子痫前期／子痫16例，对照组随机选择同期入院分娩的28例正常孕妇，测定两组患者身高、体重、血糖、胰岛素、血清瘦素水平及胰岛素敏感指数。结果子痫前期－子痫患者血清瘦素及胰岛素水平明显高于对照组（t值分别为9．55、3．61，均P＜0．05），尤其是重度子痫前期及子痫患者血清瘦素水平明显高于对照组（t＝35．55，P＝0．000），而胰岛素敏感指数显著低于对照组（t＝2．35，P＝0．022）。子痫前期－子痫患者血糖水平与对照组无显著性差异（t＝0．65，P＝0．780）。结论子痫前期－子痫患者血清瘦素水平高低与疾病的严重程度成正相关关系，对预测子痫前期－子痫时的发生有一定临床意义。检测血清瘦素、胰岛素及胰岛素敏感指数对预防子痫前期－子痫的发生有重要意义。
目的：探討子癇前期－子癇時胰島素牴抗與血清瘦素水平的關繫。方法選取子癇前期－子癇時患者36例為研究組，其中子癇前期輕度20例，重度子癇前期／子癇16例，對照組隨機選擇同期入院分娩的28例正常孕婦，測定兩組患者身高、體重、血糖、胰島素、血清瘦素水平及胰島素敏感指數。結果子癇前期－子癇患者血清瘦素及胰島素水平明顯高于對照組（t值分彆為9．55、3．61，均P＜0．05），尤其是重度子癇前期及子癇患者血清瘦素水平明顯高于對照組（t＝35．55，P＝0．000），而胰島素敏感指數顯著低于對照組（t＝2．35，P＝0．022）。子癇前期－子癇患者血糖水平與對照組無顯著性差異（t＝0．65，P＝0．780）。結論子癇前期－子癇患者血清瘦素水平高低與疾病的嚴重程度成正相關關繫，對預測子癇前期－子癇時的髮生有一定臨床意義。檢測血清瘦素、胰島素及胰島素敏感指數對預防子癇前期－子癇的髮生有重要意義。
목적：탐토자간전기－자간시이도소저항여혈청수소수평적관계。방법선취자간전기－자간시환자36례위연구조，기중자간전기경도20례，중도자간전기／자간16례，대조조수궤선택동기입원분면적28례정상잉부，측정량조환자신고、체중、혈당、이도소、혈청수소수평급이도소민감지수。결과자간전기－자간환자혈청수소급이도소수평명현고우대조조（t치분별위9．55、3．61，균P＜0．05），우기시중도자간전기급자간환자혈청수소수평명현고우대조조（t＝35．55，P＝0．000），이이도소민감지수현저저우대조조（t＝2．35，P＝0．022）。자간전기－자간환자혈당수평여대조조무현저성차이（t＝0．65，P＝0．780）。결론자간전기－자간환자혈청수소수평고저여질병적엄중정도성정상관관계，대예측자간전기－자간시적발생유일정림상의의。검측혈청수소、이도소급이도소민감지수대예방자간전기－자간적발생유중요의의。
Objective To explore the relationship between insulin resistance (IR) and serum leptin level in preeclampsia-eclampsia. Methods Totally 36 cases with preeclampsia-eclampsia were selected in study group , including 20 cases of mild preeclampsia and 16 cases of severe preeclampsia-eclampsia .Another 28 cases of normal pregnant women admitted in hospital at the same period were randomly selected in control group.The height, weight, blood glucose, insulin level, serum leptin level and insulin sensitivity index (ISI) were detected in two groups .Results The serum levels of leptin and insulin in the study group were significantly higher than those in the control group (t value was 9.55 and 3.61, respectively, both P<0.05).The serum level of leptin in patients with severe preeclampsia and eclampsia was significantly higher than that in the control group (t=35.55, P=0.000).However, ISI was significantly lower in the study group than in the control group (t=2.35,P=0.022).There was no significant difference in the level of blood glucose between two groups (t=0.65, P=0.780).Conclusion The level of serum leptin has a positive correlation with the severity of preeclampsia-eclampsia, which is important for predicting the occurrence of preeclampsia-eclampsia.Detecting serum leptin level , insulin and ISI is important in preventing preeclampsia-eclampsia.
