中国妇幼健康研究
中國婦幼健康研究
중국부유건강연구
CHINESE JOURNAL OF MATERNAL AND CHILD HEALTH RESEARCH
2014年
6期
986-988
,共3页
许如菊%赵仕勇%厉小玉%蒋茂莹
許如菊%趙仕勇%厲小玉%蔣茂瑩
허여국%조사용%려소옥%장무형
儿童%志贺菌%多重%耐药性
兒童%誌賀菌%多重%耐藥性
인동%지하균%다중%내약성
children%shigella%multiple%drug resistance
目的：进一步了解儿童多重耐药志贺菌感染的菌群分布及药敏情况。方法对杭州市儿童医院2011年4月至2013年6月就诊的14周岁以下患儿多重耐药志贺菌感染的菌群及药敏结果进行统计分析。结果在培养出多重耐药志贺菌的36名患儿中，男童23名，女童13名，男女比例为1．77：1，年龄分布10个月至9岁，平均年龄3．14±1．23岁。在收集到的36株多重耐药志贺菌中，有27株分离于0～5岁患儿粪便，占75．0％；9株分离于6～10岁患儿粪便，占25．0％。药敏结果显示，氨苄西林、庆大霉素以及头孢唑林的耐药率最高达100．0％。收集的36株志贺菌全部多重耐药，均对头孢唑林、氨苄西林、庆大霉素耐药；四重耐药只有福氏志贺菌4株，宋内志贺菌1株，共占13．9％（5／36），其余31株均为四重以上耐药，占86．1％（31／36）。结论本地区儿童疑为多重耐药志贺菌感染时，宜首选呋喃妥因、头孢他啶、头孢哌酮／舒巴坦、哌拉西林／他唑巴坦等抗菌素。
目的：進一步瞭解兒童多重耐藥誌賀菌感染的菌群分佈及藥敏情況。方法對杭州市兒童醫院2011年4月至2013年6月就診的14週歲以下患兒多重耐藥誌賀菌感染的菌群及藥敏結果進行統計分析。結果在培養齣多重耐藥誌賀菌的36名患兒中，男童23名，女童13名，男女比例為1．77：1，年齡分佈10箇月至9歲，平均年齡3．14±1．23歲。在收集到的36株多重耐藥誌賀菌中，有27株分離于0～5歲患兒糞便，佔75．0％；9株分離于6～10歲患兒糞便，佔25．0％。藥敏結果顯示，氨芐西林、慶大黴素以及頭孢唑林的耐藥率最高達100．0％。收集的36株誌賀菌全部多重耐藥，均對頭孢唑林、氨芐西林、慶大黴素耐藥；四重耐藥隻有福氏誌賀菌4株，宋內誌賀菌1株，共佔13．9％（5／36），其餘31株均為四重以上耐藥，佔86．1％（31／36）。結論本地區兒童疑為多重耐藥誌賀菌感染時，宜首選呋喃妥因、頭孢他啶、頭孢哌酮／舒巴坦、哌拉西林／他唑巴坦等抗菌素。
목적：진일보료해인동다중내약지하균감염적균군분포급약민정황。방법대항주시인동의원2011년4월지2013년6월취진적14주세이하환인다중내약지하균감염적균군급약민결과진행통계분석。결과재배양출다중내약지하균적36명환인중，남동23명，녀동13명，남녀비례위1．77：1，년령분포10개월지9세，평균년령3．14±1．23세。재수집도적36주다중내약지하균중，유27주분리우0～5세환인분편，점75．0％；9주분리우6～10세환인분편，점25．0％。약민결과현시，안변서림、경대매소이급두포서림적내약솔최고체100．0％。수집적36주지하균전부다중내약，균대두포서림、안변서림、경대매소내약；사중내약지유복씨지하균4주，송내지하균1주，공점13．9％（5／36），기여31주균위사중이상내약，점86．1％（31／36）。결론본지구인동의위다중내약지하균감염시，의수선부남타인、두포타정、두포고동／서파탄、고랍서림／타서파탄등항균소。
Objective To further understand the distribution of bacterial flora and drug susceptibility profile of multidrug resistant Shigella in children .Methods A statistical analysis was performed on the distribution of bacterial flora and drug susceptibility profile of multidrug resistant shigella in infections in children under 14 years of age between April 2011 and June 2013.Results Among 36 children infected with multidrug resistant Shigella , there were 23 boys and 13 girls with the ratio of 1.77:1.The age ranged from 10 months old to 9 years old with mean age of 3.14 ±1.23 years old.Of the 36 strains of multidrug Shigella collected , 27 (75.0%) were collected from the stool of children aged 0-5 years and 9 (25.0%) were from that of children aged 6-10 years.Drug susceptibility results showed that drug resistance to Ampicillin, Gentamycin and Cefazolin was highest (100.0%).The 36 collected strains of Shigella were multidrug resistant to Cefazolin, Ampicillin and Gentamycin .Only 4 strains of Sh.flexneri and one strain of Sh .sonnei were resistant to four drugs , occupying 13.9%(5/36), and the rest strains were resistant to more than four drugs (86.1%, 31/36).Conclusion When children suspected to be infected with multidrug resistant shigella in the local community , antibiotics including Macrodantin , Ceftazidime , CFP/TAZ and PIP/TAZ should be considered first .
