中国妇幼健康研究
中國婦幼健康研究
중국부유건강연구
CHINESE JOURNAL OF MATERNAL AND CHILD HEALTH RESEARCH
2014年
6期
969-970,1004
,共3页
围绝经期抑郁症%雌激素%单胺类递质%相关性分析
圍絕經期抑鬱癥%雌激素%單胺類遞質%相關性分析
위절경기억욱증%자격소%단알류체질%상관성분석
perimenopausal depression%estrogen%monoamine neurotransmitter%correlation analysis
目的：探讨围绝经期抑郁症与雌激素及单胺类递质水平的相关性，以分析围绝经期抑郁症的可能发病机制。方法选择2012年10月至2014年1月浙江省武义县妇幼保健院妇产科收治的围绝经期抑郁症患者53例，设为观察组；另选择同期体检的健康围绝经期妇女56例作为对照组。用汉密顿抑郁量表（ HAMD）评价受试者抑郁状况，电化学发光免疫法测定两组血清雌二醇（E2）和卵泡刺激素（FSH）水平，高效液相－电化学法测定两组血浆5－羟色胺（5-HT）和去甲肾上腺素（NE）水平。用pearson相关分析对HAMD总分与E2、FSH、5-HT和NE进行相关性检测。结果观察组E2显著低于对照组（t＝8．616，P＜0．05），FSH显著高于对照组（t＝6．668，P＜0．05）。观察组5-HT显著低于对照组（t＝9．030，P＜0．05），NE显著高于对照组（t＝4．798，P＜0．05）。 Pearson相关分析显示，HAMD总分与E2呈显著负相关（r＝－0．547，P＜0．05），与FSH呈显著正相关（r＝0．488，P＜0．05），与5-HT呈显著负相关（r＝－0．387，P＜0．05），与NE呈显著正相关（r＝0．294，P＜0．05）。结论雌激素及单胺类递质可能参与了围绝经期抑郁症的发病，并能提示病情的严重程度。
目的：探討圍絕經期抑鬱癥與雌激素及單胺類遞質水平的相關性，以分析圍絕經期抑鬱癥的可能髮病機製。方法選擇2012年10月至2014年1月浙江省武義縣婦幼保健院婦產科收治的圍絕經期抑鬱癥患者53例，設為觀察組；另選擇同期體檢的健康圍絕經期婦女56例作為對照組。用漢密頓抑鬱量錶（ HAMD）評價受試者抑鬱狀況，電化學髮光免疫法測定兩組血清雌二醇（E2）和卵泡刺激素（FSH）水平，高效液相－電化學法測定兩組血漿5－羥色胺（5-HT）和去甲腎上腺素（NE）水平。用pearson相關分析對HAMD總分與E2、FSH、5-HT和NE進行相關性檢測。結果觀察組E2顯著低于對照組（t＝8．616，P＜0．05），FSH顯著高于對照組（t＝6．668，P＜0．05）。觀察組5-HT顯著低于對照組（t＝9．030，P＜0．05），NE顯著高于對照組（t＝4．798，P＜0．05）。 Pearson相關分析顯示，HAMD總分與E2呈顯著負相關（r＝－0．547，P＜0．05），與FSH呈顯著正相關（r＝0．488，P＜0．05），與5-HT呈顯著負相關（r＝－0．387，P＜0．05），與NE呈顯著正相關（r＝0．294，P＜0．05）。結論雌激素及單胺類遞質可能參與瞭圍絕經期抑鬱癥的髮病，併能提示病情的嚴重程度。
목적：탐토위절경기억욱증여자격소급단알류체질수평적상관성，이분석위절경기억욱증적가능발병궤제。방법선택2012년10월지2014년1월절강성무의현부유보건원부산과수치적위절경기억욱증환자53례，설위관찰조；령선택동기체검적건강위절경기부녀56례작위대조조。용한밀돈억욱량표（ HAMD）평개수시자억욱상황，전화학발광면역법측정량조혈청자이순（E2）화란포자격소（FSH）수평，고효액상－전화학법측정량조혈장5－간색알（5-HT）화거갑신상선소（NE）수평。용pearson상관분석대HAMD총분여E2、FSH、5-HT화NE진행상관성검측。결과관찰조E2현저저우대조조（t＝8．616，P＜0．05），FSH현저고우대조조（t＝6．668，P＜0．05）。관찰조5-HT현저저우대조조（t＝9．030，P＜0．05），NE현저고우대조조（t＝4．798，P＜0．05）。 Pearson상관분석현시，HAMD총분여E2정현저부상관（r＝－0．547，P＜0．05），여FSH정현저정상관（r＝0．488，P＜0．05），여5-HT정현저부상관（r＝－0．387，P＜0．05），여NE정현저정상관（r＝0．294，P＜0．05）。결론자격소급단알류체질가능삼여료위절경기억욱증적발병，병능제시병정적엄중정도。
Objective To explore the correlation among perimenopausal depression , estrogen and monoamine neurotransmitter , so as to analyze the possible pathogenesis of perimenopausal depression . Methods From October 2012 to January 2014 53 patients with perimenopausal depression admitted in gynecology and obstetrics department of Maternal and Child Health Hospital of Wuyi County were selected in observation group .Another 56 healthy perimenopausal women as the same period were selected in control group .Hamilton depression scale ( HAMD) was used to evaluate the depression status .Electrochemiluminescence immunoassay was adopted to detect the levels of estradiol (E2) and follicular hormone (FSH), and High Performance Liquid Chromatography (HPLC) was used to detect the level of plasma serotonin (5-HT) and norepinephrine ( NE).The correlation between HAMD scores and E 2 , FSH, 5-HT and NE was analyzed by pearson correlation analysis .Results The level of E 2 was significantly lower but FSH was significantly higher in the observation group than in the control group (t value was 8.616 and 6.668, respectively, both P <0.05).In the observation group 5-HT was significantly lower but NE was significantly higher than in the control group (t value was 9.030 and 4.798, respectively, both P<0.05). Pearson correlation analysis showed that total scores of HAMD were negatively correlated with E 2 and 5-HT ( r value was -0.547 and-0.387, respectively, both P <0.05), and that they were positively correlated with FSH and NE (r value was 0.488 and 0.294, respectively, both P<0.05).Conclusion Estrogen and monoamine neurotransmitters may be involved in the onset of perimenopausal depression, and they can reflect the severity of the illness in a certain extent .
