中国妇幼健康研究
中國婦幼健康研究
중국부유건강연구
CHINESE JOURNAL OF MATERNAL AND CHILD HEALTH RESEARCH
2014年
6期
960-962
,共3页
谭小平%宁景春%向兰花%王芬%张汉英
譚小平%寧景春%嚮蘭花%王芬%張漢英
담소평%저경춘%향란화%왕분%장한영
高龄产妇%血管性假血友病性因子%子痫前期%低氧诱导因子%相关性
高齡產婦%血管性假血友病性因子%子癇前期%低氧誘導因子%相關性
고령산부%혈관성가혈우병성인자%자간전기%저양유도인자%상관성
aged puerperal%von Willbrand Factor ( vWF)%pre-eclampsia%hypoxia induced factor-1α( HIF-1α)%correlation
目的：探究子痫前期高龄产妇胎盘低氧诱导因子－1α（ HIF-1α）蛋白水平与外周血血管性假血友病性因子（ vWF ）浓度的相关性，为及时有效预防子痫的发生提供实验室依据。方法对30例正常分娩高龄产妇（ A组）、35例子痫前期轻度高龄产妇（ B组）、41例子痫前期重度高龄产妇（ C组）的HIF-1α蛋白水平与外周血vWF浓度进行测定，并分析HIF-1α蛋白水平与vWF浓度的相关性。结果 B组、C组的HIF-1α蛋白水平、vWF浓度显著高于A组，（ B组：t1＝13．194，P1＝0．000；t2＝4．856， P2＝0．000。 C组：t1＝17．441，P1＝0．000；t2＝9．156，P2＝0．000）；C组的HIF-1α蛋白水平、vWF浓度显著高于B组，差异均有统计学意义（t1＝9．681，P1＝0．000；t2＝4．899，P2＝0．000）。 Spearman 相关性分析显示，vWF 浓度与子痫前期的病情程度（r＝0．288，P＝0．000）、HIF-1α蛋白水平（r＝0．410，P＝0．000）均呈显著正相关关系。结论子痫前期高龄产妇的胎盘HIF-1α蛋白水平与外周血vWF浓度明显升高，二者可能共同参与子痫前期的发生和发展。
目的：探究子癇前期高齡產婦胎盤低氧誘導因子－1α（ HIF-1α）蛋白水平與外週血血管性假血友病性因子（ vWF ）濃度的相關性，為及時有效預防子癇的髮生提供實驗室依據。方法對30例正常分娩高齡產婦（ A組）、35例子癇前期輕度高齡產婦（ B組）、41例子癇前期重度高齡產婦（ C組）的HIF-1α蛋白水平與外週血vWF濃度進行測定，併分析HIF-1α蛋白水平與vWF濃度的相關性。結果 B組、C組的HIF-1α蛋白水平、vWF濃度顯著高于A組，（ B組：t1＝13．194，P1＝0．000；t2＝4．856， P2＝0．000。 C組：t1＝17．441，P1＝0．000；t2＝9．156，P2＝0．000）；C組的HIF-1α蛋白水平、vWF濃度顯著高于B組，差異均有統計學意義（t1＝9．681，P1＝0．000；t2＝4．899，P2＝0．000）。 Spearman 相關性分析顯示，vWF 濃度與子癇前期的病情程度（r＝0．288，P＝0．000）、HIF-1α蛋白水平（r＝0．410，P＝0．000）均呈顯著正相關關繫。結論子癇前期高齡產婦的胎盤HIF-1α蛋白水平與外週血vWF濃度明顯升高，二者可能共同參與子癇前期的髮生和髮展。
목적：탐구자간전기고령산부태반저양유도인자－1α（ HIF-1α）단백수평여외주혈혈관성가혈우병성인자（ vWF ）농도적상관성，위급시유효예방자간적발생제공실험실의거。방법대30례정상분면고령산부（ A조）、35례자간전기경도고령산부（ B조）、41례자간전기중도고령산부（ C조）적HIF-1α단백수평여외주혈vWF농도진행측정，병분석HIF-1α단백수평여vWF농도적상관성。결과 B조、C조적HIF-1α단백수평、vWF농도현저고우A조，（ B조：t1＝13．194，P1＝0．000；t2＝4．856， P2＝0．000。 C조：t1＝17．441，P1＝0．000；t2＝9．156，P2＝0．000）；C조적HIF-1α단백수평、vWF농도현저고우B조，차이균유통계학의의（t1＝9．681，P1＝0．000；t2＝4．899，P2＝0．000）。 Spearman 상관성분석현시，vWF 농도여자간전기적병정정도（r＝0．288，P＝0．000）、HIF-1α단백수평（r＝0．410，P＝0．000）균정현저정상관관계。결론자간전기고령산부적태반HIF-1α단백수평여외주혈vWF농도명현승고，이자가능공동삼여자간전기적발생화발전。
Objective To investigate the correlation between hypoxia induced factor-1α( HIF-1α) protein level in the placenta and concentration of von Willbrand Factor ( vWF) in peripheral blood of aged puerpera in pre-eclampsia, so as to provide laboratory basis for preventing the happening of eclampsia timely and effectively .Methods The HIF-1αprotein level and concentration of vWF of peripheral blood in 30 cases of aged normal delivery (group A), 35 cases of aged puerpera with mild pre-eclampsia (group B) and 41 cases of aged puerpera with severe pre-eclampsia (group C) were measureed, and the correlation between HIF-1αprotein level and the concentration of vWF was analyzed .Results The HIF-1αprotein level and the concentration of vWF of group B and group C were significantly higher than those of group A(group B:t1 =13.194,P1 =0.000;t2 =4.856,P2 =0.000.group C:t1 =17.441,P1 =0.000;t2 =9.156,P2 =0.000). The HIF-1αprotein level and the concentration of vWF of group C were significantly higher than those of group B (t1 =9.681,P1 =0.000;t2 =4.899,P2 =0.000).Spearman correlation analysis showed that the concentration of vWF was positively correlated with the illness severity of pre-eclampsia (r=0.288,P=0.000) and HIF-1αprotein level (r=0.410,P=0.000).Conclusion The HIF-1αprotein level and the concentration of vWF of aged puerpera in pre-eclampsia increase significantly , and they may act synergistically in development and progression of pre-eclampsia.
