CAJ | 학술논문

目的：对比分析实时二维剪切波弹性成像和实时组织弹性成像评估慢性肝病肝纤维化的价值。方法对110例行肝组织活检的慢性肝病患者同时行实时二维剪切波弹性成像和实时组织弹性成像检查，以肝组织病理学结果为金标准，比较二者与肝纤维化病理分期的相关系数、诊断肝纤维化（S ≥2）和肝硬化（S＝4）的ROC曲线下面积。结果剪切波弹性成像与肝纤维化病理分期的相关系数（ r ＝07．76，95％ CI 06．83－08．45，P ＝0.000）高于实时组织弹性成像（ r ＝05．61，95％ CI 04．07－06．84，P ＝0.000）（ Z ＝29．3，P ＝0.003）。剪切波弹性成像诊断肝纤维化（S≥2）、肝硬化（S＝4）的ROC曲线下面积分别为08．66、09．57；实时组织弹性成像为07．50、08．43。剪切波弹性成像诊断肝纤维化（S≥2）、肝硬化（S＝4）效能高于实时组织弹性成像（ P ＝0.030、0.048）。结论实时二维剪切波弹性成像诊断肝纤维化（S ≥2）、肝硬化（S＝4）效能优于实时组织弹性成像。
목적：대비분석실시이유전절파탄성성상화실시조직탄성성상평고만성간병간섬유화적개치。방법대110례행간조직활검적만성간병환자동시행실시이유전절파탄성성상화실시조직탄성성상검사，이간조직병이학결과위금표준，비교이자여간섬유화병리분기적상관계수、진단간섬유화（S ≥2）화간경화（S＝4）적ROC곡선하면적。결과전절파탄성성상여간섬유화병리분기적상관계수（ r ＝07．76，95％ CI 06．83－08．45，P ＝0.000）고우실시조직탄성성상（ r ＝05．61，95％ CI 04．07－06．84，P ＝0.000）（ Z ＝29．3，P ＝0.003）。전절파탄성성상진단간섬유화（S≥2）、간경화（S＝4）적ROC곡선하면적분별위08．66、09．57；실시조직탄성성상위07．50、08．43。전절파탄성성상진단간섬유화（S≥2）、간경화（S＝4）효능고우실시조직탄성성상（ P ＝0.030、0.048）。결론실시이유전절파탄성성상진단간섬유화（S ≥2）、간경화（S＝4）효능우우실시조직탄성성상。
Objective To compare the value of two‐dimensional shear wave elastography (2D‐SWE) and real‐time tissue elastography (RTE) in the assessment of liver fibrosis in patients with chronic liver disease. Methods One hundred and ten patients with chronic liver disease scheduled for liver biopsy were studied. Both 2D‐SWE and RTE were performed on these patients in a same day. The correlation coefficient of liver fibrosis level, receiver operating characteristic (ROC) curve of S≥2, and S=4 of 2D‐SWE and RTE were compared according to pathologic results. Results The correlation coefficient of liver fibrosis level for 2D‐SWE ( r =0 7.76, 95% CI 0 6.83 -0 8.45, P =0.000) was higher than that of RTE ( r =0 5.61, 95% CI 0 4.07-0 6.84, P =0.000)( Z =2 9.3, P =0.003). The area under ROC curve for S≥2 and S=4 of 2D‐SWE were 0 8.66 and 0 9.57 respectively, RTE were 0 7.50 and 0 8.43 respectively, which indicated that 2D‐SWE was better than RTE. Conclusions The diagnostic performance of 2D‐SWE was better than RTE for the assessment of liver fibrosis and cirrhosis.