CAJ | 학술논문

目的：探讨P21WAF1在胃肠道间质瘤（gastrointestinal stromal tumors，GIST）中表达的临床及病理意义。方法应用免疫组化Maxvision方法检测50例GIST瘤组织中P21WAF1的表达情况。结果50例GIST瘤组织中P21WAF1阳性率为48.0％，明显低于瘤旁组织阳性率76.2％。结论 P21WAF1与GIST发生发展有关，可作为CD117外的GIST的补充指标，对于明确诊断GIST有重要意义。
목적：탐토P21WAF1재위장도간질류（gastrointestinal stromal tumors，GIST）중표체적림상급병리의의。방법응용면역조화Maxvision방법검측50례GIST류조직중P21WAF1적표체정황。결과50례GIST류조직중P21WAF1양성솔위48.0％，명현저우류방조직양성솔76.2％。결론 P21WAF1여GIST발생발전유관，가작위CD117외적GIST적보충지표，대우명학진단GIST유중요의의。
Objective To investigate the expression of P21WAF1 in human gastrointestinal stromal tumors (GIST).Methods Fifty cases of GIST were evaluated for P21WAF1 protein expression by immunohistochemical meth-od.Results The positive expression level of P21WAF1 was 48.0%in human GIST,which was lower than in the adja-cent tissues(76.2%).Conclusion P21WAF1 is related to GIST, and can be used as a supplemental index of CD 117. It is helpful for the diagnosis of GIST .