CAJ | 학술논문

目的：增强对粒细胞肉瘤的临床诊断、病理及免疫组织化学、细胞遗传学改变及治疗的认识。方法对4例粒细胞肉瘤患者的临床资料进行分析，并复习相关文献。结果4例中非白血病型2例，相应治疗后持续缓解；白血病型2例，其中1例源于急性髓系白血病，另1例源于慢性髓系白血病，治疗效果均差，生存时间分别为8个月和4个月。结论粒细胞肉瘤诊断和鉴别诊断主要依靠病理形态学及免疫组织化学，其预后差。早期确诊，及时实施个体化治疗，高强度化疗可延缓复发，提高生存率，造血干细胞移植能够明显延长生存期。
목적：증강대립세포육류적림상진단、병리급면역조직화학、세포유전학개변급치료적인식。방법대4례립세포육류환자적림상자료진행분석，병복습상관문헌。결과4례중비백혈병형2례，상응치료후지속완해；백혈병형2례，기중1례원우급성수계백혈병，령1례원우만성수계백혈병，치료효과균차，생존시간분별위8개월화4개월。결론립세포육류진단화감별진단주요의고병리형태학급면역조직화학，기예후차。조기학진，급시실시개체화치료，고강도화료가연완복발，제고생존솔，조혈간세포이식능구명현연장생존기。
Objective To explore the diagnosis, clinical pathology, immunohistochemistry, cytogenetics and treatment of granulocytic sarcoma(GS). Methods The clinical data of 4 cases of GS was analyzed, and the related-literatures were reviewed. Results Two cases were non-leukemic GS, currently being in continuous complete remis-sion after appropriate treatment. The other 2 cases were leukemic GS:one case originated from acute myeloid leuke-mia, and the other one originated from chronic myeloid leukemia, the results of the two patients for treatment were poor, the survival time of the two cases was 8 months and 4 months respectively. Conclusion The diagnosis and dif-ferential diagnosis of GS mainly depends on patho-morphology and immunohistochemistry. The prognosis of GS is poor.The early diagnosis, timely implementation of the individualized treatment and early high-intensity chemothera-py can delay the recurrence and improve long-term survival rate;hematopoietic stem cell transplantation can signifi-cantly prolong survival time.