CAJ | 학술논문

通过双能X射线吸收法测量受试者的骨密度，是目前公认的诊断骨质疏松症的方法。然而，越来越多的基础和临床研究发现，骨密度的改变并不能完全解释患者骨强度的改变。大量的骨组织显微结构研究发现，松质骨的骨强度主要由骨密度、骨结构等因素决定。近年来的研究表明，在决定松质骨骨骼强度方面，骨组织的显微结构可以作为独立于骨密度之外的决定性参数。研究松质骨的力学属性和显微结构之间的关系，对于更好的理解骨质疏松的发生和对骨质疏松的诊断具有十分重要的意义。根据文献回顾，松质骨显微结构参数和表观力学强度之间关联性最为显著的为BV／TV、Tb．N、连接性、各向异性、结构模型指数等。同时笔者也对目前这些研究结果在临床上高分辨率CT上的应用情况做一总结。
통과쌍능X사선흡수법측량수시자적골밀도，시목전공인적진단골질소송증적방법。연이，월래월다적기출화림상연구발현，골밀도적개변병불능완전해석환자골강도적개변。대량적골조직현미결구연구발현，송질골적골강도주요유골밀도、골결구등인소결정。근년래적연구표명，재결정송질골골격강도방면，골조직적현미결구가이작위독립우골밀도지외적결정성삼수。연구송질골적역학속성화현미결구지간적관계，대우경호적리해골질소송적발생화대골질소송적진단구유십분중요적의의。근거문헌회고，송질골현미결구삼수화표관역학강도지간관련성최위현저적위BV／TV、Tb．N、련접성、각향이성、결구모형지수등。동시필자야대목전저사연구결과재림상상고분변솔CT상적응용정황주일총결。
Bone mineral density ( BMD) measurement using dual energy X-ray absorptiometry ( DXA) has been widely accepted as a clinical method to diagnose osteoporosis.However, more and more basic and clinical studies have indicated that the variance of cancellous bone strength cannot be fully attributed to the reduction of BMD.Many experiments about microarchitecture of cancellous bone have revealed that cancellous bone strength is determined by BMD, bone architecture and other parameters. The microarchitecture of the bone is a decisive parameter independent of BMD.It is important to study the relationship between microarchitecture and bone strength of cancellous bone in order to understand the development and diagnosis of osteoporosis.Based on literature review, we summarize that the most related parameters between microarchitecture and bone strength are BV/TV, Tb. N, connectivity, degree of Anisotropy, and structure model index.Meanwhile, the clinical application of the research results on high resolution CT is also summarized.