中国性科学
中國性科學
중국성과학
THE CHINESE JOURNAL OF HUMAN SEXUALITY
2014年
12期
5-8
,共4页
液基细胞学检查%宫颈癌%HPV-DNA 检测
液基細胞學檢查%宮頸癌%HPV-DNA 檢測
액기세포학검사%궁경암%HPV-DNA 검측
Liquid-based cervical cytology inspect%Cervical cancer%HPV-DNA screening
目的：分析液基细胞学检查在宫颈癌筛查中的诊断价值，探讨其临床适用性。方法：选择从2011年9月到2012年9月于我院进行保健筛查的645例已婚女性患者进行TCT检查，对细胞学检查筛查出的ASC－US及以上病变患者进行HPV－DNA检测和在阴道镜下进行病理组织学检查。观察各种检查方法的阳性比率及阴性比率，比较TCT检查方法和HPV－DNA 检测方法的灵敏度和特异度情况。结果：TCT检查中ASC－US 及以上病变201例，其中阴性139例，阳性62例。病理组织学检查结果：TCT阴性139例，其中组织学阴性129例，阴性率92.8％；组织学阳性10例，阳性率7.2％；TCT 阳性62例，其中组织学阴性31例，阴性率50.0％；组织学阳性31例，阳性率50.0％。而HPV－DNA检测阴性97例，阳性104例。病理组织学检查结果：HPV－DNA 阴性97例中，组织学阴性94例，阴性率96.9％，阳性3例，阳性率3.1％；HPV－DNA 阳性104例，其中组织学阴性68例，阴性率65.4％，阳性36例，阳性率34.6％。两种检测方法比较结果为TCT特异度和准确度远高于HPV－DNA检测，差异有统计学意义（P＜0.05），而HPV－DNA检测敏感度高于TCT。结论：宫颈液基细胞学检查是一种简单且准确率较高的宫颈癌和前期病变筛查方法，特异性比较强，且可以降低漏诊率，对早期检查和预防宫颈病变中具有较高的诊断价值，适合临床长期推广应用。
目的：分析液基細胞學檢查在宮頸癌篩查中的診斷價值，探討其臨床適用性。方法：選擇從2011年9月到2012年9月于我院進行保健篩查的645例已婚女性患者進行TCT檢查，對細胞學檢查篩查齣的ASC－US及以上病變患者進行HPV－DNA檢測和在陰道鏡下進行病理組織學檢查。觀察各種檢查方法的暘性比率及陰性比率，比較TCT檢查方法和HPV－DNA 檢測方法的靈敏度和特異度情況。結果：TCT檢查中ASC－US 及以上病變201例，其中陰性139例，暘性62例。病理組織學檢查結果：TCT陰性139例，其中組織學陰性129例，陰性率92.8％；組織學暘性10例，暘性率7.2％；TCT 暘性62例，其中組織學陰性31例，陰性率50.0％；組織學暘性31例，暘性率50.0％。而HPV－DNA檢測陰性97例，暘性104例。病理組織學檢查結果：HPV－DNA 陰性97例中，組織學陰性94例，陰性率96.9％，暘性3例，暘性率3.1％；HPV－DNA 暘性104例，其中組織學陰性68例，陰性率65.4％，暘性36例，暘性率34.6％。兩種檢測方法比較結果為TCT特異度和準確度遠高于HPV－DNA檢測，差異有統計學意義（P＜0.05），而HPV－DNA檢測敏感度高于TCT。結論：宮頸液基細胞學檢查是一種簡單且準確率較高的宮頸癌和前期病變篩查方法，特異性比較彊，且可以降低漏診率，對早期檢查和預防宮頸病變中具有較高的診斷價值，適閤臨床長期推廣應用。
목적：분석액기세포학검사재궁경암사사중적진단개치，탐토기림상괄용성。방법：선택종2011년9월도2012년9월우아원진행보건사사적645례이혼녀성환자진행TCT검사，대세포학검사사사출적ASC－US급이상병변환자진행HPV－DNA검측화재음도경하진행병리조직학검사。관찰각충검사방법적양성비솔급음성비솔，비교TCT검사방법화HPV－DNA 검측방법적령민도화특이도정황。결과：TCT검사중ASC－US 급이상병변201례，기중음성139례，양성62례。병리조직학검사결과：TCT음성139례，기중조직학음성129례，음성솔92.8％；조직학양성10례，양성솔7.2％；TCT 양성62례，기중조직학음성31례，음성솔50.0％；조직학양성31례，양성솔50.0％。이HPV－DNA검측음성97례，양성104례。병리조직학검사결과：HPV－DNA 음성97례중，조직학음성94례，음성솔96.9％，양성3례，양성솔3.1％；HPV－DNA 양성104례，기중조직학음성68례，음성솔65.4％，양성36례，양성솔34.6％。량충검측방법비교결과위TCT특이도화준학도원고우HPV－DNA검측，차이유통계학의의（P＜0.05），이HPV－DNA검측민감도고우TCT。결론：궁경액기세포학검사시일충간단차준학솔교고적궁경암화전기병변사사방법，특이성비교강，차가이강저루진솔，대조기검사화예방궁경병변중구유교고적진단개치，괄합림상장기추엄응용。
Objectives:To analyze the diagnostic value of liquid-based cytology in cervical cancer screen-ing,and to explore its clinical applicability.Methods:645 married women that conducted health screenings in our hospital from September 201 1 to September 2012 were selected.All the patients received TCT examination,and the HPV-DNA lesions detection and histopathological examination was carried out on patients whose cytology screening results was ASC-US or above.Observed the positive rate and negative rate with various inspection methods,and compared the sensitivity and specificity in the situation TCT inspection methods and HPV-DNA detection method. Results:The TCT examination results of 201 cases were ASC-US or above,including 139 negative and 62 positive cases.According to histopathological outcome:139 cases were TCT negative,of which 129 cases were histologically negative,negative rate of 92.8% and 10 cases were histologically positive,positive rate of 7.2%;62 cases were TCT positive,of which 31 cases were histologically negative,negative rate of 50.0%and 31 cases were histological-ly positive,positive rate of 50.0%.There were 97 cases and 104 cases HPV-DNA test negative and positive re-spectively.According to histopathological outcome:97 cases were HPV -DNA negative,of which 94 cases were histologically negative,negative rate of 96.9%,and 3 cases were positive,positive rate of 3.1%;104 cases were HPV-DNA positive,of which 68 cases were histologically negative,negative rate of 65 .4% and 36 cases were positive,positive rate of 34.6%.Comparing the results of the two detection methods,the specificity and accuracy of TCT were much higher than those of HPV-DNA testing,with statistically significant difference (P<0.05 ),but HPV-DNA detection had higher sensitivity than the TCT.Conclusions:Liquid-based cervical cytology is a sim-ple and cervical cancer and precancerous lesion screening methods of high accuracy and specificity,which,with a high diagnostic value for the early detection and prevention of cervical lesions,can reduce the rate of misdiagnosis and is suitable for long-term clinical application.
