CAJ | 학술논문

目的：建立晋城地区健康人群前臂骨密度（ BMD）的峰值骨量和标准差值，为开展周围型双能X线骨密度仪测定及骨质疏松症研究提供基础数据。方法采用韩国产双能X线骨矿测量仪（ EXA－3000）对晋城地区1400例21～55岁的健康体检人群进行左侧前臂骨密度测定，进行非优势侧（左侧）前臂远端尺桡骨的BMD值测定，并分析其年龄分布，建立晋城地区健康人群前臂远端骨密度的峰值骨量和标准差值。骨质疏松的骨量诊断以骨量峰值的均数±标准差的形式建立，均数的计算采用三次方回归方程模型进行拟合。结果男、女性前臂骨的BMD值均符合正态分布，可采用均数±标准差（ xˉ±s）的形式表示。40岁以前男、女性前臂骨的BMD值均随年龄增加而逐步上升，且各年龄段BMD值的差异有统计学意义（P＜0．05）。45岁以后男、女性前臂骨的BMD值开始下降，且50岁以后下降明显（ P＜0．05）。男、女性前臂骨的骨量峰值均出现在41～45岁年龄段。男、女性前臂远端尺桡骨的骨量峰值及标准差分别为（0．5682±0．0647）g／cm2、（0．4209±0．0689）g／cm2。结论建立了晋城地区健康人群男、女性前臂骨的骨量峰值和标准差，为周围型双能X线骨密度仪测定并开展骨质疏松症的研究提供基础数据，尤其是用于高危人群筛查，以便确定是否需要进一步开展中轴骨测量或进行药物治疗。
목적：건립진성지구건강인군전비골밀도（ BMD）적봉치골량화표준차치，위개전주위형쌍능X선골밀도의측정급골질소송증연구제공기출수거。방법채용한국산쌍능X선골광측량의（ EXA－3000）대진성지구1400례21～55세적건강체검인군진행좌측전비골밀도측정，진행비우세측（좌측）전비원단척뇨골적BMD치측정，병분석기년령분포，건립진성지구건강인군전비원단골밀도적봉치골량화표준차치。골질소송적골량진단이골량봉치적균수±표준차적형식건립，균수적계산채용삼차방회귀방정모형진행의합。결과남、녀성전비골적BMD치균부합정태분포，가채용균수±표준차（ xˉ±s）적형식표시。40세이전남、녀성전비골적BMD치균수년령증가이축보상승，차각년령단BMD치적차이유통계학의의（P＜0．05）。45세이후남、녀성전비골적BMD치개시하강，차50세이후하강명현（ P＜0．05）。남、녀성전비골적골량봉치균출현재41～45세년령단。남、녀성전비원단척뇨골적골량봉치급표준차분별위（0．5682±0．0647）g／cm2、（0．4209±0．0689）g／cm2。결론건립료진성지구건강인군남、녀성전비골적골량봉치화표준차，위주위형쌍능X선골밀도의측정병개전골질소송증적연구제공기출수거，우기시용우고위인군사사，이편학정시부수요진일보개전중축골측량혹진행약물치료。
Objective To establish the peak bone mass of bone mineral density ( BMD) and standard deviation of the forearm in healthy population in Jincheng, Shanxi, and to provide the basic data of peripheral BMD measurement using peripheral dual-energy X-ray absorptiometry for osteoporosis research.Methods A total of 1400 healthy population aging from 21 to 55 years old were recruited to measure the left forearm BMD using peripheral dual-energy X-ray absorptiometry (pDEXA, EXA-3000, Korea) and to analyze the age distribution.The peak bone mass and standard deviation of BMD in healthy population in Jincheng were established. Osteoporosis was diagnosed using mean of peak BMD value ±standard deviation.The means were calculated using cubic regression model.Results Forearm BMD value in males and females was in line with the normal distribution and could be represented as mean ±standard deviation (xˉ±s).The forearm BMD in males and females increased with age before 40 and decreased after 45, and the decrease was dramatically after 50 years old ( P<0.05) .The peak forearm BMD in both males and in females occurred in 41-45 age division, which was 0.5682 ±0.0647 g/cm2 and 0.4209 ±0.0689 g/cm2 , respectively.Conclusion The peak bone mass and standard deviation of BMD are established in healthy population of males and females in Jincheng.The basic data of peripheral BMD measurement using peripher dual-energy X-ray absorptiometry are provided.It is especially useful for screening the high risk population, so as to make sure whether it is necessary to measure axial bone further or to start drug treatment.