CAJ | 학술논문

目的：研究不同剂量环磷酰胺对雌性SD大鼠骨密度和骨微结构的影响。方法40只3月龄SD雌性大鼠随机数字表法分为环磷酰胺低剂量组、中剂量组、高剂量组和对照组，每组各10只，环磷酰胺各组分别腹腔注射不同剂量（5 mg／kg、8 mg／kg、10 mg／kg）的环磷酰胺，对照组腹腔注射等量生理盐水，每天一次，连续15天，观察大鼠骨密度及骨微结构等指标。结果不同剂量的环磷酰胺组与对照组比较，全身骨密度分别下降了9．8％、13．3％和15．6％；股骨骨小梁数目分别下降了49．8％、65．5％和72．8％；股骨骨小梁分离度则分别上升了225．2％、416．9％和577．4％。结论环磷酰胺可使大鼠骨密度降低，骨小梁数量减少，骨微结构受损，且环磷酰胺剂量越大，骨微结构受损越严重。
목적：연구불동제량배린선알대자성SD대서골밀도화골미결구적영향。방법40지3월령SD자성대서수궤수자표법분위배린선알저제량조、중제량조、고제량조화대조조，매조각10지，배린선알각조분별복강주사불동제량（5 mg／kg、8 mg／kg、10 mg／kg）적배린선알，대조조복강주사등량생리염수，매천일차，련속15천，관찰대서골밀도급골미결구등지표。결과불동제량적배린선알조여대조조비교，전신골밀도분별하강료9．8％、13．3％화15．6％；고골골소량수목분별하강료49．8％、65．5％화72．8％；고골골소량분리도칙분별상승료225．2％、416．9％화577．4％。결론배린선알가사대서골밀도강저，골소량수량감소，골미결구수손，차배린선알제량월대，골미결구수손월엄중。
Objective To investigate the effect of different doses of cyclophosphamide ( CP) on bone mineral density ( BMD) and bone microstructure in female SD rats.Methods Forty SD 3-month-old female rats were randomly divided into low dose of CP group, middle dose of CP group, high dose of CP group, and control group ( n=10 in each group) .Rats in the CP groups were intrapentonally injected with different doses of CP (5, 8, or 10 mg/kg, respectively).Rats in control group were intrapenitoneally injected with the same volume of normal saline.The injection was once a day, and lasted for 15 days.BMD and bone microstructure in rats were observed.Results BMD of the total body in different CP dose groups declined by 9.8%, 13.3%, and 15.6%, respectively, compared to that in control group.Trabecular number in the femur declined by 49.8%, 65.5%, and 72.8%, respectively.Trabecular separation of the femur increased by 225.2%, 416.9%, and 577.4%, respectively.Conclusion CP may decrease BMD and trabecular number in rats, and demage bone microstructure.The higher dose of cyclophosphamide, the more serious the damage of bone microstructure.