中国骨质疏松杂志
中國骨質疏鬆雜誌
중국골질소송잡지
CHINESE JOURNAL OF OSTEOPOROSIS
2014年
12期
1407-1410
,共4页
谢义松%尤冬春%朱建华%陈孟交%郑先波
謝義鬆%尤鼕春%硃建華%陳孟交%鄭先波
사의송%우동춘%주건화%진맹교%정선파
去势大鼠%虎潜丸%骨密度%BMP-2%骨质疏松症
去勢大鼠%虎潛汍%骨密度%BMP-2%骨質疏鬆癥
거세대서%호잠환%골밀도%BMP-2%골질소송증
Ovariectomized rats%Huqian pill%BMD%BMP-2%Osteoporosis
目的:探讨虎潜丸干预对去势大鼠骨密度及骨组织中BMP-2水平的影响。方法6个月龄的40只雌性SD大鼠随机分为手术模型组、雌激素组、虎潜丸组和假手术组。确定造模成功后,虎潜丸组给予虎潜丸煎剂浓缩液灌胃,每天一次;雌激素组给予尼尔雌醇悬浊液灌胃,每周一次;手术模型组和假手术组给予蒸馏水灌胃,每天一次。灌胃治疗12周后测量各组大鼠的骨密度及骨组织中BMP-2含量。结果虎潜丸组及雌激素组与手术模型组相比较,全身骨密度和腰椎骨密度都得到了一定提高,差异具有统计学意义(P<0.05);骨组织中BMP-2的水平也都有显著升高,差异具有统计学意义(P<0.05)。结论虎潜丸对切除卵巢后所致的骨质疏松症有明显的治疗作用,其机制可能是在一定程度地提高了组织中BMP-2的水平,从而抑制骨组织的吸收,促进骨组织的形成。
目的:探討虎潛汍榦預對去勢大鼠骨密度及骨組織中BMP-2水平的影響。方法6箇月齡的40隻雌性SD大鼠隨機分為手術模型組、雌激素組、虎潛汍組和假手術組。確定造模成功後,虎潛汍組給予虎潛汍煎劑濃縮液灌胃,每天一次;雌激素組給予尼爾雌醇懸濁液灌胃,每週一次;手術模型組和假手術組給予蒸餾水灌胃,每天一次。灌胃治療12週後測量各組大鼠的骨密度及骨組織中BMP-2含量。結果虎潛汍組及雌激素組與手術模型組相比較,全身骨密度和腰椎骨密度都得到瞭一定提高,差異具有統計學意義(P<0.05);骨組織中BMP-2的水平也都有顯著升高,差異具有統計學意義(P<0.05)。結論虎潛汍對切除卵巢後所緻的骨質疏鬆癥有明顯的治療作用,其機製可能是在一定程度地提高瞭組織中BMP-2的水平,從而抑製骨組織的吸收,促進骨組織的形成。
목적:탐토호잠환간예대거세대서골밀도급골조직중BMP-2수평적영향。방법6개월령적40지자성SD대서수궤분위수술모형조、자격소조、호잠환조화가수술조。학정조모성공후,호잠환조급여호잠환전제농축액관위,매천일차;자격소조급여니이자순현탁액관위,매주일차;수술모형조화가수술조급여증류수관위,매천일차。관위치료12주후측량각조대서적골밀도급골조직중BMP-2함량。결과호잠환조급자격소조여수술모형조상비교,전신골밀도화요추골밀도도득도료일정제고,차이구유통계학의의(P<0.05);골조직중BMP-2적수평야도유현저승고,차이구유통계학의의(P<0.05)。결론호잠환대절제란소후소치적골질소송증유명현적치료작용,기궤제가능시재일정정도지제고료조직중BMP-2적수평,종이억제골조직적흡수,촉진골조직적형성。
Objective To study the effect of Huqian pill on the modulation of bone mineral density and the level of BMP-2 in ovariectomized rats.Methods Forty 6-month-old female SD rats were randomly divided into 4 groups: model group, estrogen group, Huqian pill group, and sham operation group.After the establishment of the model, rats in Huqian pill group received concentrated liquid gavage once a day.Rats in estrogen group received nylestriol suspension once a week.Rats in model group and sham operation group received distilled water once a day.After a 12-week treatment, bone mineral density ( BMD) and BMP-2 were determined.Results BMD in Huqian pill group and estrogen group was improved comparing to that in model group, and the difference was significant ( P<0.05) .The level of BMP-2 was also improved in the bone tissue, and the difference was significant (P<0.05).Conclusion Huqian pill has an obvious treatment effect on ovariectomized rats.It can improve the level of BMP-2 in tissue, resulting in the inhibition of bone resorption and stimulation of bone formation.