实用癌症杂志
實用癌癥雜誌
실용암증잡지
THE PRACTICAL JOURNAL OF CANCER
2014年
12期
1702-1704
,共3页
胸部肿瘤%放射性肺损伤%放疗%苦参碱注射液
胸部腫瘤%放射性肺損傷%放療%苦參堿註射液
흉부종류%방사성폐손상%방료%고삼감주사액
Thoracic Tumor%Radiation-induced lung injury%Radiotherapy%Matrine injection
目的：探讨苦参碱注射液防治胸部肿瘤放疗所致的放射性肺损伤的疗效。方法将病理检查证实且需进行放疗的胸部肿瘤患者85例随机分为2组。治疗组43例于放疗第1天起静脉滴注苦参碱注射液；对照组42例给予单纯放疗。比较2组血清肿瘤坏死因子（ TNF-α）水平、KPS评分以及随访6个月期间放射性肺损伤的发生率。结果2组患者放疗2周及放疗结束时TNF-α水平显著升高，而治疗组升高幅度显著低于对照组。治疗组放疗2周及放疗结束时KPS评分较放疗前略有下降，而放疗结束后6个月显著升高，且放疗结束时及结束后6个月均显著高于对照组；治疗组早期及晚期放射性肺损伤的发生率均显著低于对照组。结论苦参碱注射液具有减少炎症因子释放和提高KPS评分作用，可有效预防放射性肺损伤，提高患者生活质量。
目的：探討苦參堿註射液防治胸部腫瘤放療所緻的放射性肺損傷的療效。方法將病理檢查證實且需進行放療的胸部腫瘤患者85例隨機分為2組。治療組43例于放療第1天起靜脈滴註苦參堿註射液；對照組42例給予單純放療。比較2組血清腫瘤壞死因子（ TNF-α）水平、KPS評分以及隨訪6箇月期間放射性肺損傷的髮生率。結果2組患者放療2週及放療結束時TNF-α水平顯著升高，而治療組升高幅度顯著低于對照組。治療組放療2週及放療結束時KPS評分較放療前略有下降，而放療結束後6箇月顯著升高，且放療結束時及結束後6箇月均顯著高于對照組；治療組早期及晚期放射性肺損傷的髮生率均顯著低于對照組。結論苦參堿註射液具有減少炎癥因子釋放和提高KPS評分作用，可有效預防放射性肺損傷，提高患者生活質量。
목적：탐토고삼감주사액방치흉부종류방료소치적방사성폐손상적료효。방법장병리검사증실차수진행방료적흉부종류환자85례수궤분위2조。치료조43례우방료제1천기정맥적주고삼감주사액；대조조42례급여단순방료。비교2조혈청종류배사인자（ TNF-α）수평、KPS평분이급수방6개월기간방사성폐손상적발생솔。결과2조환자방료2주급방료결속시TNF-α수평현저승고，이치료조승고폭도현저저우대조조。치료조방료2주급방료결속시KPS평분교방료전략유하강，이방료결속후6개월현저승고，차방료결속시급결속후6개월균현저고우대조조；치료조조기급만기방사성폐손상적발생솔균현저저우대조조。결론고삼감주사액구유감소염증인자석방화제고KPS평분작용，가유효예방방사성폐손상，제고환자생활질량。
Objective To explore the preventive effect of matrine injection on radiation-induced lung injury in patients with thoracic tumors .Methods 85 cases of thoracic tumors patients who confirmed by pathological examinations and underwent radiotherapy were randomly divided into 2 groups.The treatment group(n=43)received matrine injection from the 1st day of ra-diotherapy,the control group (n=42)received radiotherapy alone.The levels of tumor necrosis factor-α(TNF-α),KPS score,and incidence of radiation-induced lung injury within 6-month follow up were compared between the 2 groups.Results The levels of TNF-αin the 2 groups at the 2nd week and the end of radiotherapy increased obviously ,while the increasing degree in the treat-ment group was obviously smaller than that of the control group .The KPS score in the treatment group at the 2nd week and the end of radiotherapy decreased slightly ,and obviously increased 6 months after radiotherapy ,and it were also higher than those of the control group at the end of radiotherapy and 6 months after radiotherapy .The incidences of early and late radiation-induced lung injury in the treatment group were obviously lower than those of the control group .Conclusion Matrine injection can reduce inflammation factors releasing ,increase the KPS score ,effectively prevent radiation-induced lung injury and improve the life quali-ty of the patients .
