CAJ | 학술논문

目的：探讨甘露醇与吡拉西坦注射液治疗颅内肿瘤术后高颅内压的疗效及安全性。方法将76例颅内肿瘤术后高颅内压患者按照住院时间先后顺序分为对照组与观察组，各38例。对照组采用20％甘露醇快速静脉滴注，观察组采用20％吡拉西坦注射液治疗。统计2组患者临床治疗效果和不良反应及用药前、后颅内压增高体征及症状等情况。结果观察组用药起效时间、高峰时间、持续时间、降压幅度分别为（0．47±0．21） h、（1．00±0．42） h、（4．31±1．41）h、（10．81±4．41）mmHg，与对照组（0．48±0．23）h、（0．98±0．45）h、（4．35±1．37）h、（10．69±4．47）mmHg比较，P＞0．05。观察组治疗有效率为94．74％（36／38），与对照组92．11％（35／38）比较，P＞0．05；2组患者均未发生明显性不良反应，且治疗前后血常规和电解质及肝肾功能均无异常。结论相比甘露醇来说，颅内肿瘤术后高颅内压患者采用吡拉西坦注射液治疗效果相当，且二者均无明显不良反应，起效时间等指标均无明显差异性，因此临床治疗颅内肿瘤术后高颅内压患者可根据患者实际情况选择吡拉西坦注射液与甘露醇治疗。
목적：탐토감로순여필랍서탄주사액치료로내종류술후고로내압적료효급안전성。방법장76례로내종류술후고로내압환자안조주원시간선후순서분위대조조여관찰조，각38례。대조조채용20％감로순쾌속정맥적주，관찰조채용20％필랍서탄주사액치료。통계2조환자림상치료효과화불량반응급용약전、후로내압증고체정급증상등정황。결과관찰조용약기효시간、고봉시간、지속시간、강압폭도분별위（0．47±0．21） h、（1．00±0．42） h、（4．31±1．41）h、（10．81±4．41）mmHg，여대조조（0．48±0．23）h、（0．98±0．45）h、（4．35±1．37）h、（10．69±4．47）mmHg비교，P＞0．05。관찰조치료유효솔위94．74％（36／38），여대조조92．11％（35／38）비교，P＞0．05；2조환자균미발생명현성불량반응，차치료전후혈상규화전해질급간신공능균무이상。결론상비감로순래설，로내종류술후고로내압환자채용필랍서탄주사액치료효과상당，차이자균무명현불량반응，기효시간등지표균무명현차이성，인차림상치료로내종류술후고로내압환자가근거환자실제정황선택필랍서탄주사액여감로순치료。
Objective To study the efficacy and safety of mannitol and piracetam injection for postoperative high in -tracranial pressure in intracranial tumor .Methods 76 cases of intracranial tumor patients with high intracranial pressure in ac-cordance with admission time were divided into the control group and the observation group ,each with 38 cases.The control group received 20%mannitol infusion,and the observation group were treated with 20% piracetam injection.Clinical efficacy,adverse reactions ,and the signs and symptoms of increased intracranial pressure before and after treatment of the 2 groups were recorded . Results The onset time,peak time,duration,intracranial pressure reduction of the observation group were respectively (0.47 ± 0.21) h,(1 ±0.42) h,(4.31 ±1.41) h,(10.81 ±4.41) mmHg,and those of the control group were (0.48 ±0.23) h,(0.98 ±0.45) h,(4.35 ±1.37) h,(10.69 ±4.47) mmHg (P>0.05).The effective rates of the observation group and the control group were 94.74%(36/38) and 92.11%(35/38) (P>0.05);there had no obvious adverse reactions in both groups ,and blood test ,electrolytes and liver and kidney function before and after treatment had no abnormality .Conclusion Compared with mannitol,piracetam injection for postoperative high intracranial pressure in intracranial tumor has similar curative effect ,and ei-ther treatments has no obvious adverse reactions .The onset time and other indicators of the 2 treatments has no significant differ-ence,so the clinical treatment of postoperative high intracranial pressure in intracranial tumor patients should be decided accord -ing to the actual situation of patients .