CAJ | 학술논문

目的：探讨吉西他滨联合奥沙利铂方案（ GEMOX方案）合并高强度聚焦超声（ HIFU）治疗晚期胰腺癌的近期疗效和不良反应。方法选择经组织病理学或细胞学确诊的晚期胰腺癌患者52例，分为观察组和对照组各26例。对照组采用静脉滴注，吉西他滨1000 mg／m2，第1，8天，奥沙利铂130 mg／m2第1天治疗，每21天重复。观察组在对照组的基础上增加高强度聚焦超声治疗，比较2组的近期疗效和不良反应。结果观察组完全缓解1例（3．8％）、部分缓解10例（38．5％）、稳定5例（19．2％）、进展10例（38．5％），有效率为42．3％。对照组完全缓解0例、部分缓解6例（23．1％）、稳定7例（26．9％）、进展13例（50．0％），有效率为23．1％。观察组RR率明显高于对照组（P＜0．05）。观察组临床受益反应（CBR）57．7％，对照组34．6％，2组比较，差异显著（P＜0．05）。观察组无胃肠穿孔、出血、腹膜炎等并发症发生。结论吉西他滨联合奥沙利铂方案合并高强度聚焦超声治疗晚期胰腺癌可获得较好的近期疗效，且未出现不良反应，值得临床进一步推广应用。
목적：탐토길서타빈연합오사리박방안（ GEMOX방안）합병고강도취초초성（ HIFU）치료만기이선암적근기료효화불량반응。방법선택경조직병이학혹세포학학진적만기이선암환자52례，분위관찰조화대조조각26례。대조조채용정맥적주，길서타빈1000 mg／m2，제1，8천，오사리박130 mg／m2제1천치료，매21천중복。관찰조재대조조적기출상증가고강도취초초성치료，비교2조적근기료효화불량반응。결과관찰조완전완해1례（3．8％）、부분완해10례（38．5％）、은정5례（19．2％）、진전10례（38．5％），유효솔위42．3％。대조조완전완해0례、부분완해6례（23．1％）、은정7례（26．9％）、진전13례（50．0％），유효솔위23．1％。관찰조RR솔명현고우대조조（P＜0．05）。관찰조림상수익반응（CBR）57．7％，대조조34．6％，2조비교，차이현저（P＜0．05）。관찰조무위장천공、출혈、복막염등병발증발생。결론길서타빈연합오사리박방안합병고강도취초초성치료만기이선암가획득교호적근기료효，차미출현불량반응，치득림상진일보추엄응용。
Objective To evaluate the short-term efficacy and adverse reactions of gemcitabine plus oxaliplatin com-bined with high intensity focused ultrasound in the treatment of advanced pancreatic cancer .Methods 52 patients histologically or cytologiaclly confimed to be advanced pancreatic cancer were divided into the observation group and the control group , each with 26 cases.The control group were treated with gemcitabine 1 000 mg/m2 D1 and D8,plus oxaliplatin 130 mg/m2 D1 every 21 days.The observation group received high-intensity focused ultrasound therapy on the basis of the control group .Short-term effica-cy and adverse reactions of the 2 groups were compared .Results The effective rate of the observation group was 42.3%inclu-ding 1 CR(3.8%),10 PR(38.5%),5 SD(19.2%),10 PD(38.5%);and the effective rate of the control group was 23.1%, including 0 CR,6 PR(23.1%),7 SD(26.9%),13 PD(50.0%).The response rate of the observation group was significantly higher than that of the control group (P<0.05).The clinical benefit response rate of the observation group was 57.7%,and that of the control group was 34.6%,the difference of the 2 groups was significant(P<0.05).There were no gastrointestinal perfora-tion,hemorrhage ,peritonitis and other complications in the observation group .Conclusion Gemcitabine plus oxaliplatin com-bined with high intensity focused ultrasound in the treatment of advanced pancreatic cancer has good short -term efficacy without adverse reactions ,and it is worthy of further clinical application .