CAJ | 학술논문

目的：分析肾癌、前列腺癌、膀胱癌和睾丸癌全基因组关联研究（ GWAS）英文文献数据的构成特征。方法对国际最新GWAS研究数据库之一———美国国立人类基因组研究所（ NHGRI）数据库进行数据挖掘。结果应用文献计量学方法，客观分析了NHGRI的文献基本特征、第一第二阶段样本量、染色体区域相关（核苷酸多态性） SNP、风险等位基因频率、P值文献中最强SNP、优势比（odds ratio，OR）或β相关系数、实验平台及检测SNP数量8项数据，找出了泌尿生殖系统肿瘤GWAS的一些共性特征。结论8号染色体区域SNP多态性，可能是泌尿生殖系统肿瘤遗传易感区域，深入此易感区域研究，可能为阐述肿瘤发生、治疗及预后评估提供一定线索。
목적：분석신암、전렬선암、방광암화고환암전기인조관련연구（ GWAS）영문문헌수거적구성특정。방법대국제최신GWAS연구수거고지일———미국국립인류기인조연구소（ NHGRI）수거고진행수거알굴。결과응용문헌계량학방법，객관분석료NHGRI적문헌기본특정、제일제이계단양본량、염색체구역상관（핵감산다태성） SNP、풍험등위기인빈솔、P치문헌중최강SNP、우세비（odds ratio，OR）혹β상관계수、실험평태급검측SNP수량8항수거，조출료비뇨생식계통종류GWAS적일사공성특정。결론8호염색체구역SNP다태성，가능시비뇨생식계통종류유전역감구역，심입차역감구역연구，가능위천술종류발생、치료급예후평고제공일정선색。
Objective To analyze the data constitution features of genome -wide association study ( GWAS) in Renal cell carcinoma、Prostate cancer、Bladder cancer and Testicular cancer in English literature .Methods National human genome in-stitute GWAS database ,one of the latest international research database of GWAS ,was meticulously data mined .Results Using literature metrology method objectively analyzed 8 data of the NHGRI's basic characteristics of the literature ,the first and second stage of sample size , chromosomal regions associated SNPS , related risk allele frequency in the control group , P value with the strongest SNP in the literature , odds ratio or beta coefficient of correlation and experimental platform including testing the SNP number ,and found out the common characteristics of the urogenital system tumor GWAS .Conclusion Chromosome 8 regional SNP polymorphism may be the urogenital system tumor genetic susceptibility region ,and through into the susceptible area can pro-vide some clues in the treatment of cancer and prognosis assessment .