军事医学
軍事醫學
군사의학
BULLETIN OF THE ACADEMY OF MILITARY MEDICAL SCIENCES
2014年
12期
945-947
,共3页
透明细胞癌%碳酸酐酶9%预后%免疫组化
透明細胞癌%碳痠酐酶9%預後%免疫組化
투명세포암%탄산항매9%예후%면역조화
clear cell renal carcinoma%carbonic anhydrase 9%prognosis%immunohistochemistry
目的:探讨碳酸酐酶9( carbonic anhydrase 9,CA9)在肾透明细胞癌组织中表达程度与疾病预后之间的相关性。方法收集军事医学科学院附属医院泌尿外科2011年9月~2014年1月接受手术的53例肾透明细胞癌患者术后癌组织标本,并对患者进行随访,统计患者肿瘤复发情况与无疾病生存率( DFS)。通过免疫组化检测石蜡切片中CA9的表达并将其与随访结果进行整合分析。结果在随访53例肾透明细胞癌患者中,11例非转移性肾癌患者术后出现了复发病灶, DFS最长为22个月,最短为4个月,中位DFS为10个月。肿瘤复发组与对照组的免疫组化图像累积光密度值(IOD)分别为230879.84±64878.72和444993.31±146946.27,差异具有统计学意义(P<0.01)。结论肾透明细胞癌组织中CA9的低表达可能与疾病不良预后相关,可作为判断肾癌预后的指标。
目的:探討碳痠酐酶9( carbonic anhydrase 9,CA9)在腎透明細胞癌組織中錶達程度與疾病預後之間的相關性。方法收集軍事醫學科學院附屬醫院泌尿外科2011年9月~2014年1月接受手術的53例腎透明細胞癌患者術後癌組織標本,併對患者進行隨訪,統計患者腫瘤複髮情況與無疾病生存率( DFS)。通過免疫組化檢測石蠟切片中CA9的錶達併將其與隨訪結果進行整閤分析。結果在隨訪53例腎透明細胞癌患者中,11例非轉移性腎癌患者術後齣現瞭複髮病竈, DFS最長為22箇月,最短為4箇月,中位DFS為10箇月。腫瘤複髮組與對照組的免疫組化圖像纍積光密度值(IOD)分彆為230879.84±64878.72和444993.31±146946.27,差異具有統計學意義(P<0.01)。結論腎透明細胞癌組織中CA9的低錶達可能與疾病不良預後相關,可作為判斷腎癌預後的指標。
목적:탐토탄산항매9( carbonic anhydrase 9,CA9)재신투명세포암조직중표체정도여질병예후지간적상관성。방법수집군사의학과학원부속의원비뇨외과2011년9월~2014년1월접수수술적53례신투명세포암환자술후암조직표본,병대환자진행수방,통계환자종류복발정황여무질병생존솔( DFS)。통과면역조화검측석사절편중CA9적표체병장기여수방결과진행정합분석。결과재수방53례신투명세포암환자중,11례비전이성신암환자술후출현료복발병조, DFS최장위22개월,최단위4개월,중위DFS위10개월。종류복발조여대조조적면역조화도상루적광밀도치(IOD)분별위230879.84±64878.72화444993.31±146946.27,차이구유통계학의의(P<0.01)。결론신투명세포암조직중CA9적저표체가능여질병불량예후상관,가작위판단신암예후적지표。
Objective To study the expression of carbonic anhydrase 9(CA9) in clear cell renal carcinoma(ccRCC), and the relationship between the expression and recurrence .Methods Paraffin-embedded tissues from 53 ccRCC cases were collected during the past 3 years,and immunohistochemistry was used to detect the expression of CA 9.Fifty-three cases were followed up to evaluate the disease-free survival ( DFS) and recurrence .Association of CA9 expression with recurrence was then analyzed .Results Localized RCC recurred in eleven cases , the median DFS was 10 months, the integral optical density ( IOD) of the recurrent cases was 230 879 .84 ±64 878 .72 while the IOD of the thirteen nonrecurrent cases was much higher,444 993.31 ±146 946.27(P<0.01).Conclusion There might be a positive correlation between the low expression of CA9 and the recurrence of ccRCC .CA9 may help predict the ccRCC patients ’ prognosis.