CAJ | 학술논문

目的：探讨碳酸酐酶9（ carbonic anhydrase 9，CA9）在肾透明细胞癌组织中表达程度与疾病预后之间的相关性。方法收集军事医学科学院附属医院泌尿外科2011年9月～2014年1月接受手术的53例肾透明细胞癌患者术后癌组织标本，并对患者进行随访，统计患者肿瘤复发情况与无疾病生存率（ DFS）。通过免疫组化检测石蜡切片中CA9的表达并将其与随访结果进行整合分析。结果在随访53例肾透明细胞癌患者中，11例非转移性肾癌患者术后出现了复发病灶， DFS最长为22个月，最短为4个月，中位DFS为10个月。肿瘤复发组与对照组的免疫组化图像累积光密度值（IOD）分别为230879．84±64878．72和444993．31±146946．27，差异具有统计学意义（P＜0．01）。结论肾透明细胞癌组织中CA9的低表达可能与疾病不良预后相关，可作为判断肾癌预后的指标。
목적：탐토탄산항매9（ carbonic anhydrase 9，CA9）재신투명세포암조직중표체정도여질병예후지간적상관성。방법수집군사의학과학원부속의원비뇨외과2011년9월～2014년1월접수수술적53례신투명세포암환자술후암조직표본，병대환자진행수방，통계환자종류복발정황여무질병생존솔（ DFS）。통과면역조화검측석사절편중CA9적표체병장기여수방결과진행정합분석。결과재수방53례신투명세포암환자중，11례비전이성신암환자술후출현료복발병조， DFS최장위22개월，최단위4개월，중위DFS위10개월。종류복발조여대조조적면역조화도상루적광밀도치（IOD）분별위230879．84±64878．72화444993．31±146946．27，차이구유통계학의의（P＜0．01）。결론신투명세포암조직중CA9적저표체가능여질병불량예후상관，가작위판단신암예후적지표。
Objective To study the expression of carbonic anhydrase 9(CA9) in clear cell renal carcinoma(ccRCC), and the relationship between the expression and recurrence .Methods Paraffin-embedded tissues from 53 ccRCC cases were collected during the past 3 years,and immunohistochemistry was used to detect the expression of CA 9.Fifty-three cases were followed up to evaluate the disease-free survival ( DFS) and recurrence .Association of CA9 expression with recurrence was then analyzed .Results Localized RCC recurred in eleven cases , the median DFS was 10 months, the integral optical density ( IOD) of the recurrent cases was 230 879 .84 ±64 878 .72 while the IOD of the thirteen nonrecurrent cases was much higher,444 993.31 ±146 946.27(P<0.01).Conclusion There might be a positive correlation between the low expression of CA9 and the recurrence of ccRCC .CA9 may help predict the ccRCC patients ’ prognosis.