CAJ | 학술논문

目的：探讨吉西他滨联合顺铂一线治疗晚期三阴性乳腺癌的临床疗效及不良反应。方法30例晚期三阴性乳腺癌患者，采用吉西他滨联合顺铂一线放疗治疗，2个周期后评价治疗效果及不良反应。结果30例患者均可评价疗效，其中完全缓解（CR）2例（6.7％），部分缓解（PR）8例（26.6％），稳定（SD）11例（36.7％），进展（PD）9例（30．0％），总有效率（CR ＋PR）33.3％，随访1年，中位疾病进展时间5.4个月，主要不良反应为胃肠道反应、骨髓抑制，Ⅲ～Ⅳ级不良反应主要是中性粒细胞减少、血小板减少，无化疗相关死亡病例。结论吉西他滨联合顺铂治疗晚期三阴性乳腺癌近期疗效较好，不良反应可耐受，是晚期三阴性乳腺癌的有效治疗方案。
목적：탐토길서타빈연합순박일선치료만기삼음성유선암적림상료효급불량반응。방법30례만기삼음성유선암환자，채용길서타빈연합순박일선방료치료，2개주기후평개치료효과급불량반응。결과30례환자균가평개료효，기중완전완해（CR）2례（6.7％），부분완해（PR）8례（26.6％），은정（SD）11례（36.7％），진전（PD）9례（30．0％），총유효솔（CR ＋PR）33.3％，수방1년，중위질병진전시간5.4개월，주요불량반응위위장도반응、골수억제，Ⅲ～Ⅳ급불량반응주요시중성립세포감소、혈소판감소，무화료상관사망병례。결론길서타빈연합순박치료만기삼음성유선암근기료효교호，불량반응가내수，시만기삼음성유선암적유효치료방안。
Objective To observe the effect of Gemcitabine and Cisplatin in the treatment of advanced triple -negative breast cancer.Methods 30 patients with advanced triple -negative breast cancer were treated by Gemcitabine and Cisplatin.The effects were observed after at least 2 weeks′therapy.Results All 30 patients were available for objective response , CR 2 cases(6.7%), PR 8 cases(26.6%), SD 11 cases(36.7%), PD 9 cases(30.0%), and the overall response rate (CR+PR) was 33.3%.After 1 year′s follow-up, the medi-an survival duration was 5.4 months; the main treatment -related toxicities were bone marrow depression and gastrointestinal reaction.Grade Ⅲ~Ⅳtoxicity mainly included neutropenia and thrombocytopenia , and there was no related death disease.Conclusion Gemcit-abine combined with cisplatin is effective in the treatment of patients with advanced breast cancer with acceptable toxic reaction .It may be an effective regimen.