CAJ | 학술논문

目的：研究肥胖对糖脂代谢及血压的影响，并探讨其病理生理学机制。方法选取2009年4月至2012年3月在南京市大厂医院体检中心进行健康体检的肥胖患者31例作为肥胖组，33例超重患者为超重组，37例健康人作为对照组。分别测定三组研究对象的空腹血糖（ FPG）、空腹胰岛素（FINS）、总胆固醇（TC）、三酰甘油（TG）、高密度脂蛋白胆固醇（HDL-C）、尿酸（UA）、收缩压（SBP）、舒张压（DBP）、身高及体质量，计算胰岛素抵抗指数（HOMA-IR）、β细胞分泌功能指数（HO-MA-β）和体质量指数（ BMI），对各组数据进行比较。结果三组研究对象的 FPG、FINS、HOMA-IR、UA、TC、TG、HDL-C及SBP、DBP比较，差异有统计学意义（P＜0．05），HOMA-β比较差异无统计学意义（P＞0．05）；肥胖组与超重组的FINS、HOMA-IR、TG、UA均显著高于对照组（P＜0．01），HDL-C 则显著低于对照组（P＜0．01）；肥胖组FPG、TC、SBP、DBP 显著高于对照组（P ＜0．05），而超重组的与对照组比较无统计学意义（P＞0．05）；肥胖组FINS、HOMA-IR、TG、UA 显著高于超重组（P＜0．05或P＜0．01），HDL-C则显著低于超重组（P＜0．01），两组 FPG、TC、SBP、DBP 比较无统计学意义（P ＞0．05）。结论肥胖可导致胰岛素抵抗，其病理生理机制促进了代谢综合征其他组分，如血糖、血脂及血压的进展。
목적：연구비반대당지대사급혈압적영향，병탐토기병리생이학궤제。방법선취2009년4월지2012년3월재남경시대엄의원체검중심진행건강체검적비반환자31례작위비반조，33례초중환자위초중조，37례건강인작위대조조。분별측정삼조연구대상적공복혈당（ FPG）、공복이도소（FINS）、총담고순（TC）、삼선감유（TG）、고밀도지단백담고순（HDL-C）、뇨산（UA）、수축압（SBP）、서장압（DBP）、신고급체질량，계산이도소저항지수（HOMA-IR）、β세포분비공능지수（HO-MA-β）화체질량지수（ BMI），대각조수거진행비교。결과삼조연구대상적 FPG、FINS、HOMA-IR、UA、TC、TG、HDL-C급SBP、DBP비교，차이유통계학의의（P＜0．05），HOMA-β비교차이무통계학의의（P＞0．05）；비반조여초중조적FINS、HOMA-IR、TG、UA균현저고우대조조（P＜0．01），HDL-C 칙현저저우대조조（P＜0．01）；비반조FPG、TC、SBP、DBP 현저고우대조조（P ＜0．05），이초중조적여대조조비교무통계학의의（P＞0．05）；비반조FINS、HOMA-IR、TG、UA 현저고우초중조（P＜0．05혹P＜0．01），HDL-C칙현저저우초중조（P＜0．01），량조 FPG、TC、SBP、DBP 비교무통계학의의（P ＞0．05）。결론비반가도치이도소저항，기병리생리궤제촉진료대사종합정기타조분，여혈당、혈지급혈압적진전。
Objective To investigate the effect of obesity on glucolipid metabolism and blood pressure , as well as its underlying mechanism .Methods A total of 101 cases of patients underwent physical examina-tion in the healthcare center of Nanjing Dachang Hospital from Apr .2009 to Mar.2012 were randomly select-ed,including 31 obese patients as the obesity group,33 over-weight patients as the over-weight group,and 37 health people as the control group.Fasting plasma glucose(FPG),fasting insulin(FINS),total cholesterol (TC),triglyceride(TG),high density lipoprotein cholesterol(HDL-C),uric acid(UA),systolic blood pres-sure(SBP),diastolic blood pressure(DBP),body height and weight of the three groups were measured,and insulin resistance index( HOMA-IR) ,the function index of islet beta-cell( HOMA-β) and body mass index (BMI) were calculated.ANOVA was applied for the interclass comparison.Results FPG,FINS,HOMA-IR,UA,TC,TG,HDL-C,SBP and DBP differed significantly among the three groups,the differences were statistically significant(P<0.05),but HOMA-βhad no statistically significant difference(P>0.05).Com-pared with the control group,FINS,HOMA-IR,TG and UA of the obesity group and over-weight group were significantly higher(P<0.01),whereas HDL-C was significantly lower than the control group(P<0.01). FPG,TC,SBP and DBP of the obesity group were significantly higher than those of the control group ( P <0.05), while there were no statistically significant differences in those indexes between the over-weight group and the control group.Compared with the over-weight group,FINS,HOMA-IR,TG and UA of the obe-sity group were significantly higher(P<0.05 or P<0.01),and HDL-C was significantly lower(P<0.01), while there were no statistically significant differences of FPG,TC,SBP and DBP between the two groups (P>0.05).Conclusion Obesity can cause insulin resistance,its pathophysiological mechanism plays an important role in the development of metabolic syndrome .