医学综述
醫學綜述
의학종술
MEDICAL RECAPITULATE
2014年
23期
4370-4371,4374
,共3页
血清蛋白%胎儿%生长发育
血清蛋白%胎兒%生長髮育
혈청단백%태인%생장발육
Serum protein%Fetus%Growth and development
目的:探讨母血及脐血中白蛋白(sALB)、转铁蛋白(TRF)、视黄醇结合蛋白(RBP)、前白蛋白( PA)与胎儿生长发育的关系。方法选择2012年11月至2013年10月在佛山市南海区桂城医院单胎足月(≥37孕周)分娩的产妇115例,按胎儿出生体质量分为三组:低体质量(<2.5 kg)组30例,正常体质量(2.0~4.0 kg)组61例,超重组(≥4.0 kg)24例。采用血清生化及酶联免疫吸附试验检测母血及新生儿脐血中sALB、RBP、PA、TRF水平。结果母血及脐血sALB水平在三组之间的差异均无统计学意义(P>0.05)。三组中脐血RBP、PA、TRF水平显著低于母血水平(P<0.05),脐血RBP、PA、TRF 水平在低体质量组分别为(16.99±7.71) mg/L、(11.46±3.31) g/L、(1.65±0.36) g/L,在正常体质量组分别为(24.19±27.19) mg/L、(10.49±2.43)g/L、(1.69±0.47)g/L,在超重组分别为(26.68±33.33) mg/L、(13.15±4.98) g/L、(1.76±0.52) g/L;母血RBP、PA、TRF水平在低体质量组分别为(44.35±15.40) mg/L、(26.69±6.86) g/L、(4.10±0.51) g/L,在正常体质量组分别为(37.15±11.17) mg/L、(21.64±5.63) g/L、(4.00±0.47) g/L,在超重组分别为(36.22±15.59)mg/L、(20.69±5.10)g/L、(3.90±0.58)g/L。低体质量组母血及脐血 RBP、PA水平均显著低于正常体质量组(P<0.05),母血及脐血TRF水平高于正常体质量组(P<0.05);超重组母血及脐血RBP、PA水平均显著高于正常体质量组(P<0.05),母血及脐血TRF水平与正常体质量组的差异无统计学意义(P>0.05)。母血及脐血RBP、PA水平与新生儿出生体质量直接相关(r=0.482、0.437,P<0.05)。结论母血及脐血RBP、PA水平与新生儿出生体质量直接相关,是反映母儿营养状况的敏感指标。
目的:探討母血及臍血中白蛋白(sALB)、轉鐵蛋白(TRF)、視黃醇結閤蛋白(RBP)、前白蛋白( PA)與胎兒生長髮育的關繫。方法選擇2012年11月至2013年10月在彿山市南海區桂城醫院單胎足月(≥37孕週)分娩的產婦115例,按胎兒齣生體質量分為三組:低體質量(<2.5 kg)組30例,正常體質量(2.0~4.0 kg)組61例,超重組(≥4.0 kg)24例。採用血清生化及酶聯免疫吸附試驗檢測母血及新生兒臍血中sALB、RBP、PA、TRF水平。結果母血及臍血sALB水平在三組之間的差異均無統計學意義(P>0.05)。三組中臍血RBP、PA、TRF水平顯著低于母血水平(P<0.05),臍血RBP、PA、TRF 水平在低體質量組分彆為(16.99±7.71) mg/L、(11.46±3.31) g/L、(1.65±0.36) g/L,在正常體質量組分彆為(24.19±27.19) mg/L、(10.49±2.43)g/L、(1.69±0.47)g/L,在超重組分彆為(26.68±33.33) mg/L、(13.15±4.98) g/L、(1.76±0.52) g/L;母血RBP、PA、TRF水平在低體質量組分彆為(44.35±15.40) mg/L、(26.69±6.86) g/L、(4.10±0.51) g/L,在正常體質量組分彆為(37.15±11.17) mg/L、(21.64±5.63) g/L、(4.00±0.47) g/L,在超重組分彆為(36.22±15.59)mg/L、(20.69±5.10)g/L、(3.90±0.58)g/L。低體質量組母血及臍血 RBP、PA水平均顯著低于正常體質量組(P<0.05),母血及臍血TRF水平高于正常體質量組(P<0.05);超重組母血及臍血RBP、PA水平均顯著高于正常體質量組(P<0.05),母血及臍血TRF水平與正常體質量組的差異無統計學意義(P>0.05)。母血及臍血RBP、PA水平與新生兒齣生體質量直接相關(r=0.482、0.437,P<0.05)。結論母血及臍血RBP、PA水平與新生兒齣生體質量直接相關,是反映母兒營養狀況的敏感指標。
목적:탐토모혈급제혈중백단백(sALB)、전철단백(TRF)、시황순결합단백(RBP)、전백단백( PA)여태인생장발육적관계。방법선택2012년11월지2013년10월재불산시남해구계성의원단태족월(≥37잉주)분면적산부115례,안태인출생체질량분위삼조:저체질량(<2.5 kg)조30례,정상체질량(2.0~4.0 kg)조61례,초중조(≥4.0 kg)24례。채용혈청생화급매련면역흡부시험검측모혈급신생인제혈중sALB、RBP、PA、TRF수평。결과모혈급제혈sALB수평재삼조지간적차이균무통계학의의(P>0.05)。삼조중제혈RBP、PA、TRF수평현저저우모혈수평(P<0.05),제혈RBP、PA、TRF 수평재저체질량조분별위(16.99±7.71) mg/L、(11.46±3.31) g/L、(1.65±0.36) g/L,재정상체질량조분별위(24.19±27.19) mg/L、(10.49±2.43)g/L、(1.69±0.47)g/L,재초중조분별위(26.68±33.33) mg/L、(13.15±4.98) g/L、(1.76±0.52) g/L;모혈RBP、PA、TRF수평재저체질량조분별위(44.35±15.40) mg/L、(26.69±6.86) g/L、(4.10±0.51) g/L,재정상체질량조분별위(37.15±11.17) mg/L、(21.64±5.63) g/L、(4.00±0.47) g/L,재초중조분별위(36.22±15.59)mg/L、(20.69±5.10)g/L、(3.90±0.58)g/L。저체질량조모혈급제혈 RBP、PA수평균현저저우정상체질량조(P<0.05),모혈급제혈TRF수평고우정상체질량조(P<0.05);초중조모혈급제혈RBP、PA수평균현저고우정상체질량조(P<0.05),모혈급제혈TRF수평여정상체질량조적차이무통계학의의(P>0.05)。모혈급제혈RBP、PA수평여신생인출생체질량직접상관(r=0.482、0.437,P<0.05)。결론모혈급제혈RBP、PA수평여신생인출생체질량직접상관,시반영모인영양상황적민감지표。
Objective To explore the relationships between the mother blood and umbilical cord blood albumin ( sALB) , transferrin ( TRF) , retinol binding protein ( RBP) , prealbumin ( PA) and fetal growth/development.Methods From Nov.2012 to Oct.2013,115 cases of delivery of full-term(≥37 weeks) sin-gleton were selected from Guicheng Hospital of Nanhai District in Foshan ,according to the birth weight they were divided into three groups:low weight( <2.5 kg) group of 30 cases,normal weight(2.5 kg≤body mass<4.0 kg) group of 61 cases, overweight(≥4.0 kg) group of 24 cases.Serum biochemical and enzyme-linked immunosorbent assay were used to detect sALB, RBP, PA and TRP in blood and neonatal umbilical cord blood.Results Mother blood and umbilical cord blood sALB level had no significant difference between the three groups(P>0.05);umbilical cord blood RBP, PA, TRF were significantly lower than the mother blood level(P<0.05)in the three groups.Umbilical cord blood RBP,PA,TRF level of the low birth weight group were(16.99 ±7.71) mg/L,(11.46 ±3.31) g/L,(1.65 ±0.356) g/L respectively; of the normal body weight group were(24.19 ±27.19)mg/L,(10.49 ±2.43)g/L,(1.691 ±0.474)g/L respectively; of the overweight group were (26.68 ±33.33)mg/L,(13.15 ±4.98)g/L,(1.762 ±0.516)g/L respectively.The mother blood RBP,PA,TRF level of the low birth weight group were(44.35 ±15.40) mg/L,(26.69 ± 6.86)g/L,(4.10 ±0.51) g/L respectively; of the normal weight group were RBP,PA,TRF(37.15 ± 11.17)mg/L,(21.64 ±5.63)g/L,(4.00 ±0.47)g/L respectively; of the overweight group were RBP, PA,TRF(36.22 ±15.59)mg/L,(20.69 ±5.10)g/L,(3.90 ±0.58)g/L respectively.RBP, PA levels of mother blood and cord blood in low birth weight group were significantly lower than the normal birth weight group(P<0.05).TRF level of the mother blood and umbilical cord blood was higher than the normal birth weight group(P<0.05).Mother blood and umbilical cord blood RBP, PA levels of overweight group were significantly higher than the normal birth weight group(P<0.05).Mother blood and umbilical cord blood TRF had no significant difference from the normal birth weight group(P >0.05).RBP,PA levels of the mother blood and umbilical cord blood were directly related to birth weight(r=0.482,0.437,P <0.05). Conclusion RBP, PA levels of mother blood and umbilical cord blood are directly related to birth weight , which are sensitive indicators to reflect the nutritional status of mother and child .