CAJ | 학술논문

目的：探讨结核杆菌T细胞斑点试验（ T-spot．TB）在克罗恩病和肠结核鉴别诊断中的价值。方法对北京大学深圳医院2010年1月至2012年8月收治的35例克罗恩病和37例肠结核患者进行T-spot．TB、糖类抗原125（CA125）测定，比较两种检测方法检测克罗恩病和肠结核的阳性率，并比较T-spot．TB和血CA125对克罗恩病和肠结核的鉴别诊断价值。结果肠结核组T-spot．TB、血CA125检测阳性率分别为91．9％（34／37）和78．4％（29／38），均显著高于克罗恩病组的8．6％（3／37）和21．6％（9／38）（P＜0．05），T-spot．TB鉴别克罗恩病和肠结核的灵敏度、特异度、准确度、阳性预测值、阴性预测值分别为9．19％、91．4％、91．7％、91．9％和91．4％，均高于血 CA125检测。结论T-spot．TB方便快捷，敏感性和特异性高，在克罗恩病和肠结核的鉴别诊断中具有重要价值。
목적：탐토결핵간균T세포반점시험（ T-spot．TB）재극라은병화장결핵감별진단중적개치。방법대북경대학심수의원2010년1월지2012년8월수치적35례극라은병화37례장결핵환자진행T-spot．TB、당류항원125（CA125）측정，비교량충검측방법검측극라은병화장결핵적양성솔，병비교T-spot．TB화혈CA125대극라은병화장결핵적감별진단개치。결과장결핵조T-spot．TB、혈CA125검측양성솔분별위91．9％（34／37）화78．4％（29／38），균현저고우극라은병조적8．6％（3／37）화21．6％（9／38）（P＜0．05），T-spot．TB감별극라은병화장결핵적령민도、특이도、준학도、양성예측치、음성예측치분별위9．19％、91．4％、91．7％、91．9％화91．4％，균고우혈 CA125검측。결론T-spot．TB방편쾌첩，민감성화특이성고，재극라은병화장결핵적감별진단중구유중요개치。
Objective To evaluate the value of of T-cell spot.TB for differential diagnosis of Crohn′s disease and intestinal tuberculosis(ITB).Methods A total of 35 patients with CD and 37 patients with ITB admitted to Peking University Shenzhen Hospital from Jan .2010 to Aug.2012 were performed the T-cell spot of tuberculosis test (T-spot.TB),and carbohydrate antigen 125(CA125) test, and the positive rate of the two detection methods on CD and ITB were compared,and the different value of T-spot.TB and blood CA125 in the differential diagnosis of CD and ITB were compared.Results The positive rate of T-spot.TB and blood CA125 of the inteslinal tuberculosis group were 91.9%(34/37) and 78.4%(29/38),signifi-cantly higher than those of the CD group′s 8.6%(3/37) and 21.6%(9/38)(P<0.05).The sensitivity, specificity,positive predictive value, and negative predictive value of CD and ITB by T-spot.TB were 9.19%,91.4%,91.7%,91.9% and 91.4%,all higher than those by the CA125 blood test.Conclusion T-spot.TB is convenient and rapid,with high sensitivity and specificity,thus has considerable value in the differential diagnosis of CD and ITB .