CAJ | 학술논문

2型糖尿病是一种年龄、肥胖及炎症相关性疾病。随着年龄增长以及脂肪组织的积聚，炎性细胞激活以及炎性因子释放导致胰岛素靶细胞敏感性下降，形成胰岛素抵抗，即2型糖尿病前期。沉默信息调节因子相关酶类1（SIRT1）是一种组蛋白脱乙酰化酶，在哺乳动物糖脂能量代谢和生命活动中扮演重要角色；核因子κB可诱导多种炎性细胞因子，是炎性反应和细胞生存的枢纽环节。该文主要讨论SIRT1通过调节核因子κB的表达作用于2型糖尿病的发病，为2型糖尿病的预防以及治疗提供更多理论基础。
2형당뇨병시일충년령、비반급염증상관성질병。수착년령증장이급지방조직적적취，염성세포격활이급염성인자석방도치이도소파세포민감성하강，형성이도소저항，즉2형당뇨병전기。침묵신식조절인자상관매류1（SIRT1）시일충조단백탈을선화매，재포유동물당지능량대사화생명활동중분연중요각색；핵인자κB가유도다충염성세포인자，시염성반응화세포생존적추뉴배절。해문주요토론SIRT1통과조절핵인자κB적표체작용우2형당뇨병적발병，위2형당뇨병적예방이급치료제공경다이론기출。
Type 2 diabetes mellitus is a metabolic disorder relevant to aging,obesity,and inflammation. Due to aging and accumulation of fat tissues ,insulin resistance,which is the prophase of type 2 diabetes mel-litus results from the sensitivity decrease of insulin target cells caused by the activation of inflammatory cells and release of inflammatory factors .SIRT1 ( silent information regulator related enzymes-1 ) is a histone deacetylase which plays important role in the energy metabolism of glucose and lipid and life span .NF-kap-paB can induce various inflammatory cytokines,it is the key point of inflammation and cell survival.Here is to make a review of the relationship between SIRT1/NF-κB signal pathway and type 2 diabetes mellitus,in order to provide theoretical basis for the prevention and treatment for type 2 diabetes mellitus.