CAJ | 학술논문

胃癌是最常见的恶性肿瘤之一，也是世界范围内癌症相关死亡的主要原因，其发生是由多因素参与的多阶段病理过程。近年来，随着对胃癌研究的不断深入，表观遗传学逐渐成为研究热点。表观遗传学改变包括DNA甲基化、组蛋白变体、基因组印记的缺失等，其中胃癌相关基因的异常甲基化最为重要，其改变能使抑癌基因失活、原癌基因激活，在胃癌的发生、发展中起着重要的作用。
위암시최상견적악성종류지일，야시세계범위내암증상관사망적주요원인，기발생시유다인소삼여적다계단병리과정。근년래，수착대위암연구적불단심입，표관유전학축점성위연구열점。표관유전학개변포괄DNA갑기화、조단백변체、기인조인기적결실등，기중위암상관기인적이상갑기화최위중요，기개변능사억암기인실활、원암기인격활，재위암적발생、발전중기착중요적작용。
Gastric cancer is one of the most common malignancies ,and a primary reason of cancer mor-tality worldwide.Multiple factors are involved in the multi-stage pathological process of carcinoma.With the deepening study of gastric cancer, epigenetics is becoming a research hotspot.The epigenetic alterations include DNA methylation,histone modifications and genomic imprinting deletion,among which the DNA ab-errant methylation of gastric cancer-related genes is most important,since it leads to inactivation of tumor sup-pressor genes and activation of oncogenes,playing a significant role in cancer initiation and progression .