CAJ | 학술논문

微RNA（miRNA）是一类长度为21～25个核苷酸的小分子RNA。 miRNA 参与调控心血管系统的生长发育，对细胞分化、增殖、凋亡等有重要作用。目前对miRNA的发现及其生物功能的研究一直是医学领域的热点之一，已有一些研究证实miRNA是参与心血管疾病发生、发展的重要调控分子，在心脏发育、基因表达和调控中发挥重要的作用。该文将miRNA对心脏发育及其在心血管疾病中的作用予以综述，期望对深入了解miRNA的功能提供新的思路，为临床应用提供依据。
미RNA（miRNA）시일류장도위21～25개핵감산적소분자RNA。 miRNA 삼여조공심혈관계통적생장발육，대세포분화、증식、조망등유중요작용。목전대miRNA적발현급기생물공능적연구일직시의학영역적열점지일，이유일사연구증실miRNA시삼여심혈관질병발생、발전적중요조공분자，재심장발육、기인표체화조공중발휘중요적작용。해문장miRNA대심장발육급기재심혈관질병중적작용여이종술，기망대심입료해miRNA적공능제공신적사로，위림상응용제공의거。
MicroRNA( miRNA) is a kind of small RNAs with the length of about 21 to 25 nucleotides.It involves in the regulation of cardiovascular system growth,and plays an important role in cell differentiation ,pro-liferation and apoptosis.At present,study on the discovery of miRNA and its biological functions has been one of the hotspots in the field of medicine .Some studies have demonstrated miRNA is an important regulatory mole-cule participating in heart development,gene expression and regulation.Here is to make a review of miRNA′s role in heart development and cardiovascular diseases,in order to provide new ideas for the further understand-ing of the function of miRNA,and provide basis for its clinical application.