CAJ | 학술논문

类风湿关节炎（ RA）是以慢性破坏性关节病变为特征的全身性自身免疫病。关节滑膜的慢性炎症、增生，形成血管翳，侵犯关节软骨、韧带和肌腱等，造成关节软骨、骨和关节囊破坏，最终导致关节畸形和功能丧失。其发病机制比较复杂，目前尚无有效药物根治。在滑膜和骨质破坏过程中细胞因子、细胞内信号转导等多种成分发挥作用。这些成分的研究有助于进一步揭示 RA 的病理机制，进而寻找适当的的治疗靶点。
류풍습관절염（ RA）시이만성파배성관절병변위특정적전신성자신면역병。관절활막적만성염증、증생，형성혈관예，침범관절연골、인대화기건등，조성관절연골、골화관절낭파배，최종도치관절기형화공능상실。기발병궤제비교복잡，목전상무유효약물근치。재활막화골질파배과정중세포인자、세포내신호전도등다충성분발휘작용。저사성분적연구유조우진일보게시 RA 적병리궤제，진이심조괄당적적치료파점。
Rheumatoid arthritis ( RA ) is a chronic destructive joint disease characterized by systemic autoimmunedisease.Chronic synovial inflammation,hyperplasia,pannus formation,articular cartilage viola-tions,ligaments and tendons,result in articular cartilage,bone and joint capsule destruction,eventually lead to joint deformity and loss of function.The pathogenesis of RA is complex,and so far,there are no effective drugs for radical cure.The research found that various ingredients play a role in the process of destruction in synovial and bone.These studies help to further reveal the pathogenesis of RA,and thus find the appropriate therapeutic targets.