CAJ | 학술논문

吸烟可引起血脂代谢异常，机体氧化应激增加，抗氧化能力下降，降低一氧化氮生物利用度，还可直接破坏血管内皮，刺激血小板活化，最终导致平均血小板体积增加，血小板膜流动性减低，从而增加血栓形成的风险。吸烟有关的血栓性疾病的发病机制之一就是吸烟对血小板体积和膜流动性的影响。因此，吸烟可作为预测血栓性疾病的危险因子之一。该文就吸烟影响血小板体积和膜流动性的机制予以综述。
흡연가인기혈지대사이상，궤체양화응격증가，항양화능력하강，강저일양화담생물이용도，환가직접파배혈관내피，자격혈소판활화，최종도치평균혈소판체적증가，혈소판막류동성감저，종이증가혈전형성적풍험。흡연유관적혈전성질병적발병궤제지일취시흡연대혈소판체적화막류동성적영향。인차，흡연가작위예측혈전성질병적위험인자지일。해문취흡연영향혈소판체적화막류동성적궤제여이종술。
Smoking can cause abnormalities to blood lipid metabolism ,increased oxidative stress to the body,decreased antioxidant ability and bioavailability of nitric oxide .It can directly damage the vascular endothelium,and further activate platelets,resulting in the increase of average platelet volume and decrease of platelet membrane fluidity( PMF),which may increase the risk of thrombosis.One of the pathogenesis of thrombotic diseases is the influence of smoking on platelet volumn and membrane fluidity .Therefore,smoking can be a risk factor for the prediction of thrombotic diseases .Here is to make a review of the mechanism of how smoking affects platelet volume and membrane fluidity .