CAJ | 학술논문

研究表明，骨骼肌胰岛素抵抗（ IR）作为2型糖尿病发生、发展的关键步骤，与肥胖具有密切相关性。二酰甘油作为脂质代谢的中间产物对脂毒性的产生以及IR的发生、发展发挥重要作用。近期关于人类骨骼肌组织中二酰甘油诱导IR的研究出现了相互矛盾的结果，该文将讨论出现这些矛盾结果的可能原因，并且探索二酰甘油对人体新陈代谢的作用。
연구표명，골격기이도소저항（ IR）작위2형당뇨병발생、발전적관건보취，여비반구유밀절상관성。이선감유작위지질대사적중간산물대지독성적산생이급IR적발생、발전발휘중요작용。근기관우인류골격기조직중이선감유유도IR적연구출현료상호모순적결과，해문장토론출현저사모순결과적가능원인，병차탐색이선감유대인체신진대사적작용。
Skeletal muscle insulin resistance,a crucial step in the development of type 2 diabetes,is closely associated with obesity.Diacylglycerols(DAG),as an intermediate product of lipid metabolism is involved in the pathogenesis of lipotoxicity and insulin resistance .Conflicting results in the research of DAG inducinginsulin resistance in human skeletal muscle have been seen recently,and here is to discuss the possi-ble hypotheses explaining the contradictory results and further exploring the role of DAG in human metabo-lism.