CAJ | 학술논문

冠状动脉平滑肌细胞膜上存在许多大电导钙离子激活钾通道（ BK通道），该通道具有电压依赖性和钙敏感性。研究发现，腺苷三磷酸可通过激活非选择性阳离子门控通道P2 X受体使细胞外钙离子内流增加，也可以通过G蛋白偶联受体P2 Y使细胞内三磷酸肌醇敏感钙库释放钙离子，升高细胞内钙浓度，从而激活BK通道，起到扩张冠状动脉的作用。
관상동맥평활기세포막상존재허다대전도개리자격활갑통도（ BK통도），해통도구유전압의뢰성화개민감성。연구발현，선감삼린산가통과격활비선택성양리자문공통도P2 X수체사세포외개리자내류증가，야가이통과G단백우련수체P2 Y사세포내삼린산기순민감개고석방개리자，승고세포내개농도，종이격활BK통도，기도확장관상동맥적작용。
Large conductance calcium activated potassium channels are widely distributed in coronary smooth muscle cells,which have voltage-dependent and calcium-sensitive characteristics.Studies have dem-onstrated that adenosine triphosphate ( ATP ) increases calcium influx via activation of nonselective cation channel P2XR,and also increases calcium release from IP3-sensitive calcium pool by the activation of G pro-tein couple receptor P2YR,which in turn elevates intracellular calcium concentration ,activates large conduc-tance calcium-activated potassium channels and plays a role in coronary dilation .