CAJ | 학술논문

随着现代社会生活节奏的不断加快，个体承受的压力不断增加，表现为焦虑、紧张、失眠、抑郁甚至是疾病，这些因素都使机体处于一种慢性应激状态。慢性应激与神经内分泌免疫网络失衡甚至肿瘤疾病的发生、进展都有密切的关系，明确这一网络中各途径之间的关系，可为干预肿瘤提供新思路和新靶点。该文就慢性应激与下丘脑-垂体-肾上腺皮质轴、交感神经系统和免疫系统的关系及其对肿瘤发生和进展的影响予以综述。
수착현대사회생활절주적불단가쾌，개체승수적압력불단증가，표현위초필、긴장、실면、억욱심지시질병，저사인소도사궤체처우일충만성응격상태。만성응격여신경내분비면역망락실형심지종류질병적발생、진전도유밀절적관계，명학저일망락중각도경지간적관계，가위간예종류제공신사로화신파점。해문취만성응격여하구뇌-수체-신상선피질축、교감신경계통화면역계통적관계급기대종류발생화진전적영향여이종술。
With the ever-increasing pace of modern life,the individual bears more pressure and shows anxiety,tension,insomnia,depression,even diseases.These factors make body in chronic stress state.Chronic stress is closely related with the imbalance of neurol-endocrine-immune network and even tumor.Therefore a better understanding of the paths in the network can provide us more new thoughts and therapeutic targets to intervene tumor.Here is to make a review of the correlation of chronic stress with the hypothalamic-pituitary-adrenal axis,sympathetic nervous system and the immune system ,and its influence on the onset and develop-ment of tumors.