CAJ | 학술논문

目的：探讨分析血浆儿茶酚抑素( catestatin)、血管内皮生长因子( VEGF)、基质金属蛋白酶(MMP)及基质金属蛋白酶组织抑制剂(TIMP)水平与充血性心力衰竭的关系。方法选取2011年9月至2013年8月唐山市人民医院收治的48例充血性心力衰竭患者为观察组，并选取同龄的48例健康人员作为对照组，检测并比较两组及观察组中不同心功能分级的血浆catestatin、VEGF、MMP、TIMP水平，采用Logistic分析检测指标与疾病的关系。结果观察组血浆catestatin、VEGF、MMP-2、MMP-9及TIMP-1均高于对照组，且观察组心功能分级较高者的检测水平高于心功能较低者( P<0.05)；Logistic回归分析显示：血浆catestatin、VEGF、MMP-2、MMP-9及TIMP-1均是充血性心力衰竭的预测性因子(P<0.05)。结论充血性心力衰竭患者存在明显的血浆 catestatin、VEGF、MMP 及TIMP水平升高的状态，且心功能分级越高者检测水平越高。
목적：탐토분석혈장인다분억소( catestatin)、혈관내피생장인자( VEGF)、기질금속단백매(MMP)급기질금속단백매조직억제제(TIMP)수평여충혈성심력쇠갈적관계。방법선취2011년9월지2013년8월당산시인민의원수치적48례충혈성심력쇠갈환자위관찰조，병선취동령적48례건강인원작위대조조，검측병비교량조급관찰조중불동심공능분급적혈장catestatin、VEGF、MMP、TIMP수평，채용Logistic분석검측지표여질병적관계。결과관찰조혈장catestatin、VEGF、MMP-2、MMP-9급TIMP-1균고우대조조，차관찰조심공능분급교고자적검측수평고우심공능교저자( P<0.05)；Logistic회귀분석현시：혈장catestatin、VEGF、MMP-2、MMP-9급TIMP-1균시충혈성심력쇠갈적예측성인자(P<0.05)。결론충혈성심력쇠갈환자존재명현적혈장 catestatin、VEGF、MMP 급TIMP수평승고적상태，차심공능분급월고자검측수평월고。
Objective To investigate and analyze the correction between the plasma catestatin,VEGF, MMP,TIMP and congestive heart failure. Methods 48 patients with congestive heart failure in our hospital from September 2011 to August 2013 were selected as observation group,48 healthy persons with the same age were the control group,then the plasma catestatin,VEGF,MMP and TIMP of two groups were detected and compared,then the detection levels of observation group with different cardiac functional grading were compared too,and the correction between the detection indexes and disease was analyzed by Logistic analy-sis. Results The plasma catestatin,VEGF,MMP-2,MMP-9 and TIMP-1 of observation group were all higher than those of control group,and the detection levels of patients with higher cardiac functional grading were all higher than those of patients with lower cardiac functional grading(P<0. 05). Logistic analysis showed that the 5 indicators were predictive factors for congestive heart failure(P<0. 05). Conclusion The plasma cat-estatin,VEGF,MMP and TIMP of patients with congestive heart failure all show increasing trend,and the car-diac functional grading higher,the detection levels higher.